Also found in: Dictionary.
Related to diphenoxylate hydrochloride: Loperamide, Lomotil, Furazolidone
an opioid antidiarrheal that contains subclinical amounts of atropine sulfate to limit abuse.
indications It is prescribed in the treatment of noninfectious diarrhea and intestinal cramping.
contraindications Liver disease, antibiotic-associated diarrhea, or known hypersensitivity to this drug prohibits its use. It is not given to children less than 2 years of age.
adverse effects Among the more serious adverse reactions are abdominal discomfort, intestinal obstruction, skin rash, tachycardia, urinary retention, nausea, and addiction.
A smooth muscle relaxant used in combination with atropine in treating diarrhea.