di·phe·nox·y·late hydrochloride (d  f -n k s-l t)n. An oral drug that is derived from meperidine hydrochloride and counteracts peristalsis, used primarily in combination with atropine to treat diarrhea. |
diphenoxylate hydrochloride
[dī′fənok′silāt]
an opioid antidiarrheal that contains subclinical amounts of atropine sulfate to limit abuse.
indications It is prescribed in the treatment of noninfectious diarrhea and intestinal cramping.
contraindications Liver disease, antibiotic-associated diarrhea, or known hypersensitivity to this drug prohibits its use. It is not given to children less than 2 years of age.
adverse effects Among the more serious adverse reactions are abdominal discomfort, intestinal obstruction, skin rash, tachycardia, urinary retention, nausea, and addiction.
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