DPP4

(redirected from dipeptidyl-peptidase 4)

DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
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The Company's drug pipeline consists of one product in Phase II/III clinical development for an orphan indication in a neuromuscular disease -- as well as an advanced preclinical pipeline, including calpain inhibitors for Duchenne Muscular Dystrophy, MC4-receptor antagonists for cancer cachexia and Dipeptidyl-peptidase 4 inhibitors for Type 2 diabetes.
Thiazolidinediones, sulfonylureas, meglitinides, dipeptidyl-peptidase 4 (DPP-4) inhibitors, amylin agonists and alpha-glucosidase inhibitors are some of the different treatment classes available to type 2 diabetics - some are oral medications, whereas others must be injected.
Medications for type 2 diabetes come in various classes, including alpha-glucosidase inhibitors, amylin agonists, dipeptidyl-peptidase 4 (DPP-4) inhibitors, meglitinides, sulfonylureas, and thiazolidinediones.

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