dioxygenases


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dioxygenases

enzymes which incorporate both atoms of O2 into one substrate. Less common than mono-oxygenases. Important example is the 15-15′-dioxygenase enzyme in the small intestine which cleaves plant carotenoids containing provitamin A activity, such as β-carotene, into retinal. This enzyme is absent from felines, such as the cat, and is the reason cats are dependent on animal sources of vitamin A.
References in periodicals archive ?
When the levels of α-KG are abnormally low, another class of enzymes called dioxygenases don't function properly, resulting in a host of additional disturbances," Dr.
That this base has been established without the action of TET dioxygenases, which do not contain a mitochondrial targeting sequence, suggests other modes for demethylation and ultimately metabolic reprogramming that could be mediated via cross-talk with the nucleus (Bellizzi et al.
Detection of Meta-and Ortho-Cleavage Dioxygenases in Bacteria phenol-degraders.
5-mC can be further modified to 5-hydroxymethyl Cytosine (5-hmC) by the TET family of methyl-cytosine dioxygenases.
Their topics include copper dioxygenases, energy conversion and conservation by cytochrome oxidases, the structure and reactivity of copper-oxygen species revealed by competitive oxygen-18 isotope effects, chemical reactivity in copper active-oxygen complexes, supramolecular copper dioxygen chemistry, and organic synthetic methods using copper oxygen chemistry.
Microbial degradation of alkanes (natural attenuation) involves an initial oxidation of n-alkanes to their corresponding primary alcohol by enzymes such as monoxygenases, dioxygenases, and hydroxylases (Wentzel et al.
Bacteria act on the degradation of the PAHs through the production of dioxygenases, which incorporate atoms of oxygen at benzenic ring, resulting in the formation of cis dihydrodiol, followed by some dehydroxylated intermediates that enter in the TCA-cycle (KANALY; HARAYAMA, 2000).
Dihydroxyl-substituted aromatic compound, one hydroxyl in ortho (catechol) position relative to the other hydroxyl group, can be cleaved by ring-cleavage dioxygenases.
Winfield, "Enzymatic Cleavage of Aromatic Rings: Mechanistic Aspects of the Catechol Dioxygenases and later Enzymes of Bacterial Oxidative Cleavage Pathways," Nat.
Coverage includes the biogeochemistry of nickel and its release into the environment; the impact of nickel on the metabolism of cyanobacteria and eukaryotic plants; the complex formation of nickel with amino acids and peptides, and with sugar residues, nucleobases, phosphates, ucleosides, and nucleic acids; synthetic models for the active sites of nickel- containing enzymes; the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, and methyl-coenzyme M reductases; chaperones of nickel metabolism; the role of nickel in environmental adaptation of the gastric pathogen Helicobacer pylori; nickel-dependent gene expression; and nickel toxicity and carcinogenesis.
Furukawa and collaborators applied the combined approaches of site-directed mutagenesis and Family Shuffling[TM] of genes to broaden the recognition spectrum of biphenyl dioxygenases [5].
Lipoxygenases are dioxygenases found ubiquitously in higher plants and animals.