When the levels of α-KG are abnormally low, another class of enzymes called dioxygenases
don't function properly, resulting in a host of additional disturbances," Dr.
That this base has been established without the action of TET dioxygenases
, which do not contain a mitochondrial targeting sequence, suggests other modes for demethylation and ultimately metabolic reprogramming that could be mediated via cross-talk with the nucleus (Bellizzi et al.
Detection of Meta-and Ortho-Cleavage Dioxygenases
in Bacteria phenol-degraders.
5-mC can be further modified to 5-hydroxymethyl Cytosine (5-hmC) by the TET family of methyl-cytosine dioxygenases
Their topics include copper dioxygenases
, energy conversion and conservation by cytochrome oxidases, the structure and reactivity of copper-oxygen species revealed by competitive oxygen-18 isotope effects, chemical reactivity in copper active-oxygen complexes, supramolecular copper dioxygen chemistry, and organic synthetic methods using copper oxygen chemistry.
Microbial degradation of alkanes (natural attenuation) involves an initial oxidation of n-alkanes to their corresponding primary alcohol by enzymes such as monoxygenases, dioxygenases
, and hydroxylases (Wentzel et al.
Bacteria act on the degradation of the PAHs through the production of dioxygenases
, which incorporate atoms of oxygen at benzenic ring, resulting in the formation of cis dihydrodiol, followed by some dehydroxylated intermediates that enter in the TCA-cycle (KANALY; HARAYAMA, 2000).
Dihydroxyl-substituted aromatic compound, one hydroxyl in ortho (catechol) position relative to the other hydroxyl group, can be cleaved by ring-cleavage dioxygenases
Winfield, "Enzymatic Cleavage of Aromatic Rings: Mechanistic Aspects of the Catechol Dioxygenases
and later Enzymes of Bacterial Oxidative Cleavage Pathways," Nat.
Coverage includes the biogeochemistry of nickel and its release into the environment; the impact of nickel on the metabolism of cyanobacteria and eukaryotic plants; the complex formation of nickel with amino acids and peptides, and with sugar residues, nucleobases, phosphates, ucleosides, and nucleic acids; synthetic models for the active sites of nickel- containing enzymes; the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases
, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, and methyl-coenzyme M reductases; chaperones of nickel metabolism; the role of nickel in environmental adaptation of the gastric pathogen Helicobacer pylori; nickel-dependent gene expression; and nickel toxicity and carcinogenesis.
Furukawa and collaborators applied the combined approaches of site-directed mutagenesis and Family Shuffling[TM] of genes to broaden the recognition spectrum of biphenyl dioxygenases
Lipoxygenases are dioxygenases
found ubiquitously in higher plants and animals.