The plant contains saponins; these are glycosides, such as diosgenin, dioscin
and dioscorin, and are used in the manufacture of steroids.
is a natural steroid saponin that presents in various plants.
It is synthesized through UV irradiation of dioscin
, which is extracted from Chinese yams or soybeans.
Diosgenin, a steroid sapogenin of the saponin dioscin
, can undergo oxidation to produce a progesterone-like structure that has been used to synthesize human sex hormones and to treat conditions that are regulated by these hormones.
Autophagy inhibition enhances apoptosis induced by dioscin
in huh7 cells.
Its glucoside derivative dioscin
reverses adriamycin-induced Multidrug-Resistant (MDR) through down-regulating MDR1 expression via NF-kB signaling pathway inhibition in K562 cells (Wang et al.
Background: We previously reported the effect of dioscin
on human gastric carcinoma SGC-7901 cells, but its effects on other gastric cancers are still unknown.
Hypothesis/purpose: We investigated whether dioscin
and methylprotodioscin isolated from the root of Asparagus cochinchinensis (Lour.
1) and its glycoside dioscin
as steroid intermediate to synthesize steroid hormone such as cortical hormone, sex hormone and progestogen in the pharmaceutical industry (Nie et al.
Based on these finding, the methanol extract was fractionated on silica gel column chromatography in a bioassay-guided fractionation affording two known steroidal saponins showing potent activity, dioscin
(1) and polyphyllin D (2).
Dioscorea batatas contains steroidal saponin, dioscin
and phenolic compounds like batatasin I, II, III which are dormancy inducing.
sitosterol, diosgenin, ruscogenin, [beta]-sitosterol- [betal]-D-glucoside, dioscin
and furostanol glycoside.