Hypothesis/purpose: We investigated whether dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis (Lour.
Study design: Confluent NCI-H292 cells were pretreated with dioscin or methylprotodioscin for 30 min and then stimulated with EGF or PMA for 24 h.
Results: (1) Dioscin and methylprotodioscin suppressed the expression of MUC5AC mucin gene induced by EGF or PMA; (2) dioscin suppressed the production of MUC5AC mucin induced by either EGF at [10.
Diosterol(TM) is standardized to contain bioactive fractions rich in steroidal furostanolic saponins and glycosides: Progenin III, Pseudoprotodioscin, Methyl Protodioscin, Dioscin
, Protodioscin, Iridoid Glycosides, Diosgenin and 5a-Hydroxy Laxogenin.
Diosgenin, a steroid sapogenin of the saponin dioscin
, can undergo oxidation to produce a progesterone-like structure that has been used to synthesize human sex hormones and to treat conditions that are regulated by these hormones.
restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-[kappa]B signaling inhibition.
Reversal effect of Dioscin
on multidrug resistance in human hepatoma HepG2/adriamycin cells.
1) and its glycoside dioscin
as steroid intermediate to synthesize steroid hormone such as cortical hormone, sex hormone and progestogen in the pharmaceutical industry (Nie et al.
Based on these finding, the methanol extract was fractionated on silica gel column chromatography in a bioassay-guided fractionation affording two known steroidal saponins showing potent activity, dioscin (1) and polyphyllin D (2).
Keywords: Paris polyphylla Anthelmintic activity Steroidal saponins Dactylogyrus intermedius Polyphyllin D Dioscin
Dioscorea batatas contains steroidal saponin, dioscin
and phenolic compounds like batatasin I, II, III which are dormancy inducing.
sitosterol, diosgenin, ruscogenin, [beta]-sitosterol- [betal]-D-glucoside, dioscin
and furostanol glycoside.