Oral exposure of dimethylarsinic acid
, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis.
Chromatographic separation and identification of products from the reaction of dimethylarsinic acid
with hydrogen sulfide.
Laboratory Procedure Manual: Arsenobetaine, Arsenocholine, Trimethylarsine Oxide, Monomethylarsonic Acid, Dimethylarsinic Acid
, Arsenous (III) Acid, Arsenic (V) Acid, Total Arsenic.
causes apoptosis in HL-60 cells via interaction with glutathione.
Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid
(DMA) in humans, and the methylation pattern demonstrates large interindividual differences.
In vitro biotransformation of dimethylarsinic acid
and trimethylarsine oxide by anaerobic microflora of mouse cecum analyzed by HPLC-ICP-MS and HPLC-ESI-MS.
Metabolic conversion of inorganic As (iAs) to dimethylarsinic acid
(DMA) reduces toxicity and facilitates urinary As (uAs) elimination, but the intermediate metabolite monomethylarsonic (MMA) may have increased cytoxic and genotoxic effects.
Key WORDS: arsenic, Bangladesh, cobalamin, creatinine, dimethylarsinic acid
, folate, homocysteine, monomethylarsonic acid, one-carbon metabolism.
METHODS: We used hydride generation-atomic absorption spectrometry (HGAAS) to determine iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid
RESULTS: In supermarket-bought rice, arsenic was present entirely in the inorganic form compared to greenhouse-grown rice (using irrigation water contaminated with sodium arsenate), where most (~ 86%) arsenic was present as dimethylarsinic acid
Effects of dietary dimethylarsinic acid
on the urine and urothelium of rats.
Arsenic is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid
(DMA) via one-carbon metabolism, a biochemical pathway that is dependent on folate.