dihydroxycholecalciferol

dihydroxycholecalciferol

 [di″hi-drok″se-ko″le-kal-sif´er-ol]
a group of active metabolites of cholecalciferol (vitamin D3), numbered according to the carbon atom(s) on which a hydroxyl group is substituted. 1,25-Dihydroxycholecalciferol (calcitriol) is the most active derivative; it increases intestinal absorption of calcium and phosphate, enhances bone resorption, and prevents rickets, and, because of these activities at sites distant from the site of its synthesis, is considered to be a hormone.

dihydroxycholecalciferol

/di·hy·droxy·cho·le·cal·cif·e·rol/ (-ko″le-kal-sif´ĕ-rol) a group of active metabolites of cholecalciferol (vitamin D3). 1,25-Dihydroxycholecalciferol (1,25-dihydroxyvitamin D3 or calcitriol) increases intestinal absorption of calcium and phosphate, enhances bone resorption, and prevents rickets, and, because of these activities at sites distant from the site of its synthesis, is considered to be a hormone. See also calcitriol.

dihydroxycholecalciferol

(dī″hī-drŏk″sē-kō″lē-kăl-sĭf′ĕ-rŏl)
One of the vitamin D analogs and metabolites that influence the body's absorption and use of calcium and phosphorus. Vitamin D and its analogs prevent and are used to treat rickets, osteodystrophy, hypocalcemia, and hypophosphatemia.

dihydroxycholecalciferol

a group of active metabolites of cholecalciferol (vitamin D3) numbered according to the carbon atom(s) on which a hydroxyl group is substituted. 1,25-Dihydroxycholecalciferol (calcitriol) is the most active derivative; the 25-hydroxylation occurs in the liver under the influence of substrate concentration whereas the second 1-hydroxylation occurs in the kidney mitochondria under regulation by parathyroid hormone in response to decreases in plasma calcium concentration. 1α,25-Dihydroxycholecalciferol acts like a steroid hormone stimulating calcium absorption from the small intestine and calcium mobilization from bone.
References in periodicals archive ?
Dendritic cells from human tissues express receptors for the immunomodulatory vitamin D3 metabolite, dihydroxycholecalciferol.
It is a proprietary high-dose oral formulation of 1,25 dihydroxycholecalciferol (a naturally occurring hormone and the biologically active form of vitamin D) designed for cancer therapy.
3] (cholecalciferol) is produced in the skin by the action of ultraviolet light on dehydrocholestrol which is then hydroxylated in the liver and kidneys (which needs parathyroid hormone to activate alphahydroxylase) to 1,25 dihydroxycholecalciferol, the active form of vitamin D.