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dihydrostreptomycin

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dihydrostreptomycin
an aminoglycoside antibiotic produced by the hydrogenation of streptomycin; ototoxic with damage to sensory end organs.


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Major groups of traditional ototoxic agents in humans Aminoglycosides Cytotoxic agents Amikacin Bleomycin Dihydrostreptomycin Carboplatinum Gentamicin Cisplatinum Kanamycin Nitrogen mustard Neomycin Vincristine Netilmicin Streptomycin Others Tobramycin Acetylsalicylic acid Arsenicals Loop diuretics Quinine Table 2.
Unlike its predecessor, dihydrostreptomycin is much more cochleotoxic than it is vestibulotoxic; in fact, it is almost exactly as cochleotoxic as streptomycin is vestibulotoxic.
 
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