dihydrolipoic acid


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di·hy·dro·li·po·ic ac·id

(dī-hī'drō-lip-ō'ik as'id),
Reduced lipoic acid, formed by cleavage of the -S-S- bond as a result of the acceptance of two hydrogens. Compare: lipoic acid.

dihydrolipoic acid

an essential coenzyme of pyruvic oxidase.
References in periodicals archive ?
Alpha-lipoic acid (LA) and its reduced form, dihydrolipoic acid (DHLA), have received widespread attention as antioxidants with both preventative and therapeutic uses in humans and laboratory animals.
Antioxidant and prooxidant activities of a-lipoic acid and dihydrolipoic acid.
In addition to cellular energy production, lipoic acid and its reduced form, dihydrolipoic acid, are potent antioxidants that both directly and indirectly scavenge reactive oxygen species, free radicals, and peroxides that cause widespread oxidative stress and cellular damage.
Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species.
3 Alpha lipoic acid and its reduced metabolic product dihydrolipoic acid (DHLA) both inhibited formation of beta-amyloid fibrils from beta-amyloid protein in vitro.
Conjugation directly to the surface of dihydrolipoic acid functionalized QDs is facilitated by polyhistidine metal-affinity coordination.
Brian Day, National Jewish Medical and Research Center, to test the ability of lipoic acid, dihydrolipoic acid, and thioredoxin to reverse or prevent pulmonary injury caused by sulfur mustard
Cardiac recovery during post-ischaemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.
Alpha]-Lipoic acid, in its reduced dihydrolipoic acid form, is capable of recycling other antioxidants such as vitamin E, coenzyme Q10, vitamin C and glutathione.
This research sought to determine the effects of cigarette smoke on internally produced antioxidants -- such as dihydrolipoic acid (DHLA) and glutathione -- and externally supplied antioxidants (vitamin C), as assessed by the appearance of oxidized lipid and modified proteins.
alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury.
Along with its reduced form dihydrolipoic acid (DHLA), LA reduces and recycles cellular antioxidants such as glutathione, and chelates zinc, copper and other transition metal ions in addition to heavy metals.

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