dihydrolipoic acid


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di·hy·dro·li·po·ic ac·id

(dī-hī'drō-lip-ō'ik as'id),
Reduced lipoic acid, formed by cleavage of the -S-S- bond as a result of the acceptance of two hydrogens. Compare: lipoic acid.

dihydrolipoic acid

an essential coenzyme of pyruvic oxidase.
References in periodicals archive ?
10, 11) ALA and its derivative dihydrolipoic acid (DHLA) quench a number of reactive oxygen species in both lipid and aqueous phases, chelate transition metals, prevent membrane lipid peroxidation along with protein damage via interactions with vitamin C and glutathione and thus they are considered as potent antioxidants.
Huge interest has been garnered in recent times on the antioxidant properties of a-LA and its reduced form dihydrolipoic acid (DHLA).
Abbreviation List ALB: Albumin ALT: Alanine aminotransferase ANOVA: One-way analysis of variance AP: Alkaline phosphatase AST: Aspartate aminotransferase BHT: Butylated hydroxytoluene CAT: Catalase CD: Crohn's disease CRP: C reactive protein d: Day DB: Direct bilirubin DHLA: Dihydrolipoic acid DNA: Deoxyribonucleic acid DSS: Dextran sodium sulfate DTNB: 5,5-Dithiobis-2-nitrobenzoic acid GI: Gastrointestinal GLOB: Globulin GPx: Glutathione peroxidase GR: Glutathione reductase GR GSH: Glutathione reduced GSSG: Dlutathione oxidized [H.
Alpha-lipoic acid (LA) and its reduced form, dihydrolipoic acid (DHLA), have received widespread attention as antioxidants with both preventative and therapeutic uses in humans and laboratory animals.
In addition to cellular energy production, lipoic acid and its reduced form, dihydrolipoic acid, are potent antioxidants that both directly and indirectly scavenge reactive oxygen species, free radicals, and peroxides that cause widespread oxidative stress and cellular damage.
05), (13) Additionally, both lipoic acid and dihydrolipoic acid (DHLA), the reduced form of lipoic acid, have metal chelating capabilities.
Hence, the peak obtained with copper(n) present is considered to be as a result of the reducing reaction of the copper(I) complex formed with dihydrolipoic acid [8].
3 Alpha lipoic acid and its reduced metabolic product dihydrolipoic acid (DHLA) both inhibited formation of beta-amyloid fibrils from beta-amyloid protein in vitro.
Conjugation directly to the surface of dihydrolipoic acid functionalized QDs is facilitated by polyhistidine metal-affinity coordination.
Brian Day, National Jewish Medical and Research Center, to test the ability of lipoic acid, dihydrolipoic acid, and thioredoxin to reverse or prevent pulmonary injury caused by sulfur mustard
Cardiac recovery during post-ischaemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.
Alpha]-Lipoic acid, in its reduced dihydrolipoic acid form, is capable of recycling other antioxidants such as vitamin E, coenzyme Q10, vitamin C and glutathione.

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