dihydrolipoamide acetyltransferase


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di·hy·dro·lip·o·am·ide a·ce·tyl·trans·fer·ase

(dī-hī'drō-lip-ō-am'īd ăs'e-til-trans'fĕr-ās)
An enzyme transferring acetyl from S6-acetyldihydrolipoamide to coenzyme A. A part of many enzyme complexes (e.g., pyruvate dehydrogenase complex).
Synonym(s): lipoate acetyltransferase, thioltransacetylase A.
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References in periodicals archive ?
Autoantibodies of primary biliary cirrhosis recognize dihydrolipoamide acetyltransferase and inhibit enzyme function.
An autoimmune marker, anti-mitochondrial antibody (AMA), is found in almost all patients with PBC; although other diseases may be associated with positive AMA, in PBC the antibody is directed against the pyruvate dehydrogenase complex (so-called M2 type of AMA), particularly to dihydrolipoamide acetyltransferase (E2) and E3-binding protein (107).
Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA line of branched chain alpha-keto acid dehydro genase dihydrolipoamide acetyltransferase, the 52 kD mitochondrial antigen.

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