dihydrofolic acid


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dihydrofolic acid

/di·hy·dro·fol·ic ac·id/ (-fo´lik) any of the folic acids in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism.
References in periodicals archive ?
Cotrimoxazole [Trimethoprim-sulfamethoxazole] is a sulfonamide antibiotic that interferes with bacterial folic acid synthesis by inhibiting dihydrofolic acid formation from para-aminobenzoic acid and by inhibiting dihydrofolic acid reduction to tetrahydrofolate.
Trimethoprim is an analog of a portion of another substrate in the pathway, dihydrofolic acid, and competes with it for the enzyme that catalyzes its conversion to tetrahydrofolic acid.