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dihydrofolate reductase |
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dihydrofolate reductase enzyme catalyzing the conversion of folate to 5,6,7,8-tetrahydrofolate, which is the key carrier of one-carbon units in purine and pyridime synthesis, the pathway for the breakdown of histidine and the synthesis of S-adenosylmethionine from S-adenosylhomocysteine. This enzyme is the target for methotrexate, which inhibits enzyme action, a key means of inducing remissions in acute leukemias. |
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That year, a research group reported that tumor cells which resist the chemotherapeutic drug methotrexate harbor double minute chromosomes composed of many copies of the gene that encodes dihydrofolate reductase, an enzyme that deactivates the drug (SN: 1/3/87, p. Talotrexin is a novel nonpolyglutamatable antifolate drug which has demonstrated improved antitumor activity in a broad spectrum of preclinical cancer models by targeting dihydrofolate reductase (DHFR) to prevent DNA synthesis and inhibit tumor growth. One tool was based on the dihydrofolate reductase (DHFR) gene (10) and the other on the Cryptosporidium oocyst wall protein (COWP) gene (11). |
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dihydrofolate reductase
