dihydrofolate


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dihydrofolate

/di·hy·dro·fo·late/ (DHF) (-fo´lāt) an ester or dissociated form of dihydrofolic acid.
References in periodicals archive ?
F32-ART5 did not differ from F32-TEM with regard to resistance gene markers, some of which were wild-type (chloroquine resistance transporter, dihydrofolate reductase, and cytochrome B) and others harbored mutations (multidrug resistance 1, ATPase6, [Na.
Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, ultimately inhibiting DNA synthesis, repair, and cellular replication.
Methotrexate works by blocking the action of a key enzyme, dihydrofolate reductase (DHFR), which cancer cells require to thrive.
Quadruple mutations in dihydrofolate reductase of Plasmodium falciparum isolates from Car Nicobar Island, India.
8] Methotrexate is a folic acid antagonist that inhibits dihydrofolate reductase, which reduces folic acid to tetrahydrofolate, essential in the synthesis of DNA and RNA.
Through a discretionary allocation of 1 million core-hours at the Argonne Leadership Computing Facility (ALCF), researchers at Cloud Pharmaceuticals will use Mira, a 10- petaflops IBM Blue Gene/Q supercomputer to investigate inhibitors of the dihydrofolate reductase enzyme, or DHFR, from multiple sources.
Through a discretionary allocation of 1 million core-hours at the Argonne Leadership Computing Facility (ALCF), researchers at Cloud Pharmaceuticals will use Mira, a 10-petaflops IBM Blue Gene/Q supercomputer to investigate inhibitors of the dihydrofolate reductase enzyme, or DHFR, from multiple sources.
Additionally, unlike synthetic folic acid supplements, 5-MTHF reduces the potential for masking symptoms of vitamin B12 deficiency and reduces interactions with drugs that inhibit the enzyme dihydrofolate reductase, low levels of which have been linked to folate deficiency.
The basic principle of its therapeutic efficacy is related to the inhibition of dihydrofolate reductase, a key enzyme in the folic acid metabolism, which converts dihydrofolicacid to tetrahydrofolic acid.
Methotrexate (MTX) is one of the oldest and highly efficacious antineoplastic drugs; inhibit dihydrofolate reductase, blocking the conversion of dihydrofolic acid to tetrahydrofolic acid which is an essential coenzyme required for one carbon transfer reactions in denovo purine synthesis and amino acid inter conversion.
Differential effect of regional drug pressure on dihydrofolate reductase and dihydropteroate synthetase mutations in southern Mozambique.
It is structurally very similar to folic acid and binds preferentially to dihydrofolate reductase, the enzyme responsible for conversion of folic acid to folinic acid.