dihydroartemisinin


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dihydroartemisinin

(dī-hī-drō'ahr-te-mis'i-nin),
An active metabolite of the antimalarial artemisinin.
References in periodicals archive ?
0-3h], in which young ring stages were exposed to 700 nmol/L dihydroartemisinin for 6 h, the survival rate of F32-ART5 parasites was similar to that for F32-ART3, and much higher than survival rates for F32-TEM and F32-ART parasites before acquisition of the K13 M476I mutation (10) (Table 2; online Technical Appendix Figure 1).
Thus, while crucial for understanding potential differences in their respective pharmacokinetics, binding of artemisinin derivatives, such as dihydroartemisinin or artesunate, to SA proteins under physiological conditions has never been investigated yet.
For binding analysis, stock solutions (2 mM) of artemisinin, dihydroartemisinin and artesunate were prepared in 10 mM phosphate buffer, 150 mM sodium chloride, pH 7.
Cytotoxicity of Artemisinin, a dimer of dihydroartemisinin, artemisitene and eupatoriopicrin as evaluated by the MTT and clonogenic assay.
Quantitative analysis of arteemether and its metabolites dihydroartemisinin in human plasma by LC in tandem with mass spectrometry.
Oral artesunate is hydrolysed rapidly back to the metabolite dihydroartemisinin (DHA), which is intrinsically more active as antimalaria agent.
50] values to dihydroartemisinin were [approximately equal to] 10 nmol/L (12).
This study aimed at determining the prevalence of malaria in HIV-infected individuals and also evaluate the outcome of malaria treatment with dihydroartemisinin on CD4, viral load and parasitaemia level of such individuals in Benin City.
3 nmol/L Lumefantrine 19 nmol/L 29 nmol/L Monodesethylamodiaquine 47 nmol/L 17 nmol/L Dihydroartemisinin 1.
The data presented essentially point to an absence of in vitro resistance to dihydroartemisinin (dhART) in the panel of African isolates studied, with 1 of 397 isolates having an elevated 50% inhibitory concentration ([IC.
In Response: The original title of our article was "Lack of Plasmodium falciparum in Vitro and Genomic Resistance to Dihydroartemisinin in Travelers Returning to France from Africa.
We assessed the in vitro susceptibility to dihydroartemisinin (dhART), the biologically active metabolite of artemisinin derivatives, of P.