dihydro-orotate

di·hy·dro-or·o·tate

(dī-hī'drō-ōr'ŏ-tāt)
l-5,6-dihydroorotate; an intermediate in the biosynthesis of pyrimidines.
References in periodicals archive ?
Teriflunomide reduces B- and T-cell proliferation by reversibly inhibiting the mitochondrial enzyme dihydro-orotate dehydrogenase (Warnke et al.
The metabolite is a reversible inhibitor of the mitochondrial enzyme dihydro-orotate dehydrogenase (DHODH) that exerts anti-inflammatory, antiproliferative, and immunosuppressive effects, but the mechanisms by which it does so are not yet completely understood.
Its ability to inhibit dihydro-orotate dehydrogenase (DHODH), a key cellular enzyme involved in de novo pyrimidine synthesis appears to dominate its therapeutic effect.