digitoxin


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digitoxin

 [dij″ĭ-tok´sin]
a cardiotonic glycoside obtained from Digitalis purpurea and other species of the same genus; used in the treatment of congestive heart failure. It has a slowly developing action and slow elimination. Parenteral solutions should be diluted when given intravenously.

dig·i·tox·in

(dij'i-tok'sin),
A cardioactive glycoside obtained from the leaves of Digitalis purpurea; it is more completely absorbed from the gastrointestinal tract than is digitalis. Largely eliminated by hepatic metabolism.

digitoxin

/dig·i·tox·in/ (-tok´sin) a cardiotonic glycoside from Digitalis purpurea and other Digitalis species; used similarly to digitalis.

digitoxin

(dĭj′ĭ-tŏk′sĭn)
n.
A highly active glycoside, C41H64O13, derived from digitalis and prescribed in the treatment of certain cardiac conditions.

digitoxin

[dij′itok′sin]
a cardiac glycoside obtained from leaves of Digitalis purpurea. Digitoxin differs in many ways from digoxin, including having a far greater half-life and a different route of elimination.
indications It is prescribed in the treatment of congestive heart failure and certain cardiac arrhythmias.
contraindications Ventricular fibrillation, ventricular tachycardia, or known hypersensitivity to this drug prohibits its use.
adverse effects The most serious adverse reactions are cardiac arrhythmias and heart block, disorientation, and visual disturbances.

digitoxin

Cardiology A cardiac glycoside used like digoxin, which binds more strongly to proteins, but for a similar pharmacologic effect, requires a 10-fold greater concentration

dig·i·tox·in

(dij'i-tok'sin)
A cardioactive glycoside obtained from the leaves of Digitalis purpurea; it is more completely absorbed from the gastrointestinal tract than is digitalis. Also called crystalline digitalin.

digitoxin

a poisonous glycoside contained in digitalis, an extract from the foxglove; it is a powerful heart stimulant.

digitoxin

(dij´itok´sin),
n brand names: Crystodigin, Digitaline;
drug class: cardia glycoside;
action: inhibits the formation of sodium-potassium ATPase, which makes more calcium available for contractile proteins;
uses: congestive heart failure (CHF), atrial fibrillation, paroxysmal atrial flutter, atrial tachycardia.

digitoxin

a cardiotonic glycoside obtained from Digitalis purpurea and other species of the same genus; used in the treatment of congestive heart failure.
References in periodicals archive ?
The IIIA subdomain is the most active in accommodating many ligands, for example, digitoxin, ibuprofen, tryptophan, aspirin show almost equal distributions between binding sites located in IIA and IIIA subdomains, while warfarin occupies a single site in subdomain IIA of site I.
Other anticancer agents discussed include dipyridamole, digitoxin, and azelaic acid.
Metabolites of digoxin as well as related compounds, including digitoxin, tanshinones, bufandienolide, and oleander, can contribute to or independently produce digoxin toxicity (2,3).
In addition to digoxin-like immunoreactive factor, other cross-reactants, such as progesterone (7), digitoxin (8), or oleandrin (3), have been reported to suppress recovery of digoxin in various immunoassays.
Trunzler G, Schuler E (1962) Vergleichende Studien uber Wirkungen eines Crataegus-Extraktes, von Digitoxin, Digoxin und g-Strophanthin am isolierten Warmbluter-herzen.
Apart from steroids, weaker negative interference for the AxSYM assay has been reported for digitoxin, bufalin (a cardioactive component of the Chinese medicines Chan Su and Lu-Shen-Wan), and oleandrin, a compound not in clinical use (11, 12, 21, 35, 36).
The effect of heparin on serum protein binding of digitoxin and digoxin.
Ouabain (G-strophanthin) octahydrate, ouabagenin, dihydroouabain, digoxin, digitoxin, digoxigenin, and other related steroids (aldosterone, bufalin, cortisone, hydrocortisone, progesterone, [beta]-estradiol, estrone, testosterone, and dehydroepiandrosterone), bovine thyroglobulin, and sodium cyanoborohydride were obtained from Sigma.
Effect of digoxin Fab antibody on the measurement of total and free digitoxin by fluorescence polarization and a new chemiluminescent immunoassay.
The affinity of digitoxin for binding to Fab fragments is 10-fold lower than that of digoxin; however, it is high enough to allow clinical utility of Fab fragments in cases of digitoxin intoxication as well (3).
Drugs used for treatment of congestive heart failure include cardiac glycosides such as digoxin and digitoxin, diuretics (e.