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diffusion defect

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diffusion defect,
any impairment in the diffusion of oxygen across the alveolar-capillary membrane caused by pathologic changes in any of the structures of the membrane. Specific causes may include fibrosis, granuloma, interstitial edema, and proliferation of connective tissue.


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Case 1 demonstrated an individual with an isolated diffusion defect, whereas the others tended to display a combination of restrictive and/or obstructive disease with a reduced DL CO.
The reasons for the hypoxia were universally chalked up to the usual suspects which were either chronic obstructive pulmonary disease, a diffusion defect or some vague notion that there was a sleep related hypoventilation syndrome.
 
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