diffusion defect

diffusion defect

any impairment in the diffusion of oxygen across the alveolar-capillary membrane caused by pathological changes in any of the structures of the membrane. Specific causes may include fibrosis, granuloma, interstitial edema, and proliferation of connective tissue.
References in periodicals archive ?
Home oxygen therapy is often provided to patients with IPF because of the diffusion defect they experience due to the thickened alveolar-capillary membrane caused by fibrosis of the alveolar epithelium.
The reasons for the hypoxia were universally chalked up to the usual suspects which were either chronic obstructive pulmonary disease, a diffusion defect or some vague notion that there was a sleep related hypoventilation syndrome.
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