mesangial proliferative glomerulonephritis

(redirected from diffuse mesangial proliferation)

mes·an·gi·al pro·lif·er·a·tive glo·mer·u·lo·ne·phri·tis

glomerulonephritis characterized clinically by nephrotic syndrome and histologically by diffuse glomerular increases in endocapillary and mesangial cells and in mesangial matrix; in some cases, there are mesangial deposits of IgM and complement.

mes·an·gi·al pro·lif·er·a·tive glo·mer·u·lo·ne·phri·tis

(mes-an'jē-ăl prō-lif'ĕr-ă-tiv glō-mer'yū-lō-nĕ-frī'tis)
Disorder characterized clinically by the nephrotic syndrome and histologically by diffuse glomerular increases in endocapillary and mesangial cells and in mesangial matrix; in some cases, there are mesangial deposits of IgM and complement.
References in periodicals archive ?
CLASS III###IIIb: Diffuse Mesangial Proliferation with
CLASS IV###IVb: Diffuse Mesangial Proliferation with
Histopathological diagnoses of six patients who underwent biopsy because of resistance to steroid were as follows: focal segmental glomerulosclerosis (n=3), C1q nephropathy (n=1), diffuse mesangial proliferation (n=1) and membraneous nephropathy (n=1).
The histopathological diagnoses of 6 steroid-resistant patients who underwent biopsy included FSGS (n=3), C1q nephropathy (n=1), diffuse mesangial proliferation (n=1) and membraneous nephropathy (n=1).
The major finding on light microscopy is focal or more often diffuse mesangial proliferation and matrix expansion.
The morphologic features at light microscopy may vary from MCD-like to diffuse mesangial proliferation to segmental sclerosis.
32) Similar to IgM nephropathy, C1q nephropathy may present with features resembling MCD, diffuse mesangial proliferation, or FSGS, but in this case patients tend to be either resistant or dependent to steroid therapy.

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