diffuse large cell lymphoma


Also found in: Acronyms.

diffuse large cell lymphoma

one of the most common types of aggressive lymphoma, comprising about 20% of all cases of non-Hodgkin lymphoma; the patients' median age is 57 years. The cell of origin is the B lymphocyte despite its prior classification as one of the histiocytic lymphomas. About 20% of the cases have good evidence for a follicular center cell origin due to the presence of the BCL-2 gene rearrangement. As aggressive malignancies with a tendency to metastasize, most eventually demonstrate some extranodal component, including the gastrointestinal tract, testes, skin, central nervous system, or bone.

diffuse large cell lymphoma

(1) Diffuse large B-cell lymphoma (DLBCL), see there.
 
(2) A complex and heterogeneous group of non-Hodgkin lymphomas (NHLs), which includes the “histiocytic” lymphoma and reticulum cell sarcoma of older classifications, and affects patients around age 60. They are composed of round cells with little cytoplasm that may present in advanced stages. 80% of DLCLs are of B-cell lineage, 15% of T-cell origin and 5% unclassifiable. 20% may be accompanied by monoclonal gammopathy.
 
Prognosis
60% 5-year survival
References in periodicals archive ?
1) Many recent studies have used immunophenotypic markers to subclassify diffuse large cell lymphomas into prognostic groups or groups with similar behavior.
AID is expressed in germinal center B-cell like and activated B-cell-like diffuse large cell lymphomas and is not correlated with intraclonal heterogeneity.
The prognostic impact of bone marrow involvement in patients with diffuse large cell lymphoma varies according to the degree of infiltration and presence of discordant marrow involvement.
Four subjects had CLL/SLL, 2 had mantle cell lymphoma, one had follicular grade III, 4 had diffuse large cell lymphoma (DLC), and one had lymphoplasmacytic low grade lymphoma.
The fourth retreated patient developed CD20-positive diffuse large cell lymphoma and became PET negative after retreatment with Rituxan.
The combination of 2 different types of NHL composed of small cleaved cell lymphoma and diffuse large cell lymphoma is the most common variant, accounting for up to 58% of cases.
The company plans to begin a phase II clinical trial for Pretarget Lymphoma in patients with diffuse large cell lymphoma, and in patients with follicular lymphoma, by year-end 2002.
Grogan TM, Lippman SM, Spier CM, Slymen DJ, Rybski JA, Rangel CS, Richter LC, Miller TP Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67.
Follicular lymphomas and diffuse large cell lymphomas represent the most common subtypes of primary lymphoma in the cervix and are usually classified as Ann Arbor stage I or II.

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