diffuse large cell lymphoma


Also found in: Acronyms.

diffuse large cell lymphoma

one of the most common types of aggressive lymphoma, comprising about 20% of all cases of non-Hodgkin lymphoma; the patients' median age is 57 years. The cell of origin is the B lymphocyte despite its prior classification as one of the histiocytic lymphomas. About 20% of the cases have good evidence for a follicular center cell origin due to the presence of the BCL-2 gene rearrangement. As aggressive malignancies with a tendency to metastasize, most eventually demonstrate some extranodal component, including the gastrointestinal tract, testes, skin, central nervous system, or bone.

diffuse large cell lymphoma

(1) Diffuse large B-cell lymphoma (DLBCL), see there.
 
(2) A complex and heterogeneous group of non-Hodgkin lymphomas (NHLs), which includes the “histiocytic” lymphoma and reticulum cell sarcoma of older classifications, and affects patients around age 60. They are composed of round cells with little cytoplasm that may present in advanced stages. 80% of DLCLs are of B-cell lineage, 15% of T-cell origin and 5% unclassifiable. 20% may be accompanied by monoclonal gammopathy.
 
Prognosis
60% 5-year survival
References in periodicals archive ?
The combination of 2 different types of NHL composed of small cleaved cell lymphoma and diffuse large cell lymphoma is the most common variant, accounting for up to 58% of cases.
1 patient with diffuse large cell lymphoma achieved partial response with progression free survival for 135 days
Diffuse Large Cell Lymphoma (DLCL) and Transformed Follicular Lymphoma are the two most common types of NHL, accounting for approximately 45 percent of all new non NHL cases.
Target Diseases for This Collaboration are Diffuse Large Cell Lymphoma, Transformed Follicular Lymphoma, and Chronic Lymphocytic Leukemia
The businessman from Cartori based in Stratford-upon-Avon, was diagnosed with aggressive Diffuse Large Cell Lymphoma.
We report 7 cases of diffuse large cell lymphoma with distinct paracortical localization, with malignancy confirmed by light-chain restriction and/or gene rearrangement studies as well as AID expression.
Follicular lymphomas and diffuse large cell lymphomas represent the most common subtypes of primary lymphoma in the cervix and are usually classified as Ann Arbor stage I or II.
Grogan TM, Lippman SM, Spier CM, Slymen DJ, Rybski JA, Rangel CS, Richter LC, Miller TP Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67.
SNS01-T is designed to selectively kill B-cell cancers like multiple myeloma, and, mantle cell and diffuse large cell lymphomas while leaving healthy cells unharmed.

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