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Leishmania (Leishmania) amazonensis is able to produce a wide spectrum of diseases in humans, including localized cutaneous leishmaniasis (LCL), diffuse cutaneous leishmaniasis (DCL), mucocutaneous leishmaniasis (MCL) and VL (Barral et al.
Exposure of phosphatidylserine on Leishmania amazonensis isolates is associated with diffuse cutaneous leishmaniasis and parasite infectivity.
Diffuse cutaneous leishmaniasis produces disseminated and chronic skin lesions resembling those of lepromatous leprosy and is difficult to treat.
After promising results were obtained with miltefosine in a patient with anergic diffuse cutaneous leishmaniasis (ADCL) in Venezuela (2), the patient received 150 mg/day oral miltefosine (Impavido, Zentaris, Germany) for 98 days and the lesional parasite load was quantified with quantitative nucleic acid sequence-based amplification (3).
Antigenic differences of Leishmania amazonensis isolates causing diffuse cutaneous leishmaniasis.
American Cutaneous Leishmaniasis (ACL) comprises cutaneous, mucocutaneous and diffuse cutaneous leishmaniasis (Handman 2000).

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