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diffuse alveolar damage

   Also found in: Acronyms 0.01 sec.
diffuse alveolar damage
DAD The histologic findings in ARDS, which is characterized by an acute onset of diffuse pulmonary infiltrates Etiology AIDS, air embolism, cardiopulmonary bypass, connective tissue disease–SLE, rheumatoid arthritis, scleroderma, dermatomyositis, drugs–therapeutic–eg, bleomycin, busulfan, cytoxan, MTX, nitrofurantoin or drugs of abuse, eosinophilic granuloma, heat injury, hemosiderosis, high altitude, iatrogenic–PEEP, infections–viruses–eg, herpes, CMV; protozoans–eg, toxoplasma, pneumocystis, molar pregnancy, noxious fumes–eg beryllium, cadmium, mercury, zinc, toxins–eg ammonia, kerosene, paraquat, phosgene, or gases–eg CO2, NO2, acute pancreatitis, shock, uremia. See Adult respiratory distress syndrome.


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Histologic examination of postmortem pulmonary biopsy specimen showed diffuse alveolar damage and fibrosis, real-time PCR detected enterovirus, and viral cultures were negative.
Lung histology demonstrates diffuse alveolar damage superimposed on the existing fibrotic lung.
Previous studies suggest that apoptosis plays a role in the pathogenesis of a diverse group of fibrosing lung diseases, including diffuse alveolar damage, idiopathic pulmonary fibrosis (Kuwano et al.
 
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