Research in WP2 will use the information gained from WP1 to develop ways of alleviating the differentiation block in AML and so deliver new agents for use in differentiation therapy
The concept of differentiation therapy has been viewed as a promising and revolutionary approach for the treatment of AML and other cancers for forty years ago.
These results suggest MEMAC may have useful potential for differentiation therapy of leukemic diseases.
This finding may help the designing of new protocols for T-ALL differentiation therapy in the future.
Although differentiation therapy has been widely studied in AML, there are few investigations on acute lymphoblastic leukemia, perhaps because ALL is considered a disease of differentiated lymphocytes (79).
for myelodysplastic syndrome.
Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy
in the treatment of advanced cancer.
Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies with minimal toxicity, such as differentiation therapy
is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.
Regarding these progresses, differentiation therapy
is also considered for treatment of other AML patients.
Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) "Institute Without Walls" is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies, such as differentiation therapy
Ansan's butyric acid derivatives employ a novel approach to cancer treatment called differentiation therapy
, which causes rapidly growing, immature cells to become growth-regulated, differentiated cells.