differentiation therapy

differentiation therapy

a cancer therapy technique in which the malignant cell is regarded as having escaped the normal controls of cell growth and differentiation. The cancer cell is regarded as pathologically arrested at an early stage of differentiation, retaining the ability to proliferate. It is treated with agents that remove this block and allow the cells to differentiate along more normal lines until they eventually lose their ability to divide and replicate.

differentiation therapy

Oncology A strategy used to treat malignancies with a block in the normal cell differentiation; the intent with DT is to drive malignant cells into a mature nonproliferating state of remission

differentiation therapy

The use of medications to make cancer cells evolve into cells no longer capable of infinite replication.
References in periodicals archive ?
The company has commenced confirmatory screening of small molecule hits that can turn off the function of NR2F6 as a part of the Company's Differentiation Therapy Platform.
Research in WP2 will use the information gained from WP1 to develop ways of alleviating the differentiation block in AML and so deliver new agents for use in differentiation therapy.
The concept of differentiation therapy has been viewed as a promising and revolutionary approach for the treatment of AML and other cancers for forty years ago.
Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy in the treatment of advanced cancer.
Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies with minimal toxicity, such as differentiation therapy.
The silencing of the expression of this orphan nuclear receptor suggests that this is a logical therapeutic target for differentiation therapy using gene silencing technology.
Differentiation therapy is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.
Regarding these progresses, differentiation therapy is also considered for treatment of other AML patients.
Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) "Institute Without Walls" is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies, such as differentiation therapy.
Christine Ichim, the Company's Director of Molecular Therapeutics presented preclinical data regarding its DiffronC technology( a constituent of its Differentiation Therapy Platform) at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Stockholm, Sweden on June 24[sup.
Researchers from Johns Hopkins University School of Medicine reasoned that combining epigenetic therapy, entinostat, with differentiation therapy, retinoic acid receptor beta 2 agonist (ATRA) will provide an effective combination of drugs against TNBC.