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a synthetic nonsteroidal estrogen used for palliative treatment of prostatic carcinoma and sometimes advanced breast carcinoma. It was formerly used to relieve vasomotor symptoms associated with menopause, and in primary ovarian failure, female hypogonadism, atrophic vaginitis, kraurosis vulvae, and female castration. Most significantly, however, it was formerly widely used to prevent threatened abortion and premature labor. The female children who were thus exposed to the drug as fetuses have tended to have a variety of cervical abnormalities and an increased risk of clear cell adenocarcinoma of the reproductive tract. Male offspring have sometimes had abnormal genitalia, epididymal cysts, and abnormal semen analyses. Regular examinations and follow-up are indicated for these individuals.
di·eth·yl·stil·bes·trol (DES),(dī-eth'il-stil-bes'trol), Avoid the misspelling/mispronunciation diethylstilbesterol.
A synthetic nonsteroidal estrogenic compound. Sometimes used as a postcoital antipregnancy agent to prevent implantation of the fertilized ovum. The first demonstrated transplacental carcinogen responsible for a delayed clear cell vaginal carcinoma in female offspring of mothers who took the drug during pregnancy when the drug was erroneously thought to prevent threatened abortion.
diethylstilbestrol/di·eth·yl·stil·bes·trol/ (DES) (-stil-bes´trol) a synthetic nonsteroidal estrogen, used as the base or the diphosphate salt for the palliative treatment of prostatic carcinoma and sometimes breast carcinoma; it is an epigenetic carcinogen and females exposed to it in utero are subject to increased risk of vaginal and cervical carcinomas.
n. Abbr. DES
A nonsteroidal synthetic drug, C18H20O2, having estrogenic properties and used in the treatment of advanced prostate cancer. Before 1971 it was prescribed to prevent miscarriage and to treat menstrual disorders but was found to cause vaginal cancer and other reproductive abnormalities in the daughters of pregnant women so treated.
a synthetic hormone with estrogenic properties. This agent was used extensively from 1948 to 1971 to decrease miscarriages, but it is now contraindicated because it is known to increase the risk of vaginal clear cell carcinoma in the women exposed to it in utero (i.e., daughters of mothers who used the drug). Also called stilbestrol.
A synthetic nonsteroidal estrogenic compound; sometimes previously used as a postcoital antipregnancy agent to prevent implantation of the fertilized oocyte. The first demonstrated transplacental carcinogen responsible for a delayed clear-cell vaginal carcinoma in girls born to mothers who took the drug during pregnancy when it was erroneously thought to prevent miscarriage.
This is a synthetic estrogen drug that is used to treat a number of hormonal conditions. However, it causes problems in developing fetuses and should not be taken during pregnancy. From about 1938 to 1971, DES was given to pregnant women because it was thought to prevent miscarriage. Children of women who took the drug during pregnancy are at risk for certain health problems.
A synthetic nonsteroidal estrogenic compound; formerly used as a postcoital antipregnancy agent to prevent implantation of the fertilized oocyte.
a synthetic nonsteroidal estrogen; abbreviated DES. In cattle used to treat infertility and as a stimulant to weight gain by increasing muscular development. Its use is limited as a weight gain stimulant because of the possible entry of the compound into the human food chain. Excessive, long-term administration causes anal prolapse, abortion, fracture of the pelvis and nymphomaniac behavior. Sometimes used in dogs to treat misalliance and urinary incontinence, but limited by its myelotoxic effects.