dicyclomine


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Related to dicyclomine: dicyclomine hydrochloride

dicyclomine

 [di-si´klo-mēn]
an anticholinergic and antimuscarinic with effects similar to those of atropine; the hydrochloride salt is used as a gastrointestinal antispasmodic.

dicyclomine (dicycloverine (UK))

Bentyl, Bentylol (CA), Diclophen (CA), Formulex (CA), Lomine (CA), Merbentyl (UK), Protylol (CA)

Pharmacologic class: Anticholinergic

Therapeutic class: Antispasmodic

Pregnancy risk category B

Action

Thought to exert direct effect on GI smooth muscle by inhibiting acetylcholine at receptor sites, thereby reducing GI tract motility and tone

Availability

Capsules: 10 mg

Solution for injection: 10 mg/ml

Syrup: 10 mg/5 ml

Tablets: 20 mg

Indications and dosages

Irritable bowel syndrome in patients unresponsive to usual interventions

Adults: 20 mg P.O. or I.M. q.i.d.; may increase up to 160 mg/day

Contraindications

• Hypersensitivity to drug
• GI or genitourinary tract obstruction
• Severe ulcerative colitis
• Reflux esophagitis
• Unstable cardiovascular status
• Glaucoma
• Myasthenia gravis

dicyclomine

/di·cy·clo·mine/ (-si´klo-mēn) an anticholinergic, used as the hydrochloride salt as a gastrointestinal antispasmodic.

dicyclomine

(dī-sī′klə-mēn′)
n.
An anticholinergic drug, C19H35NO2, used in its hydrochloride form to relax smooth muscle and as an antispasmodic in the treatment of irritable bowel syndrome and other gastrointestinal disorders.

dicyclomine

an anticholinergic; the hydrochloride is used as a gastrointestinal antispasmodic.
References in periodicals archive ?
Dicyclomine is the generic version of Bentyl(R), a product of Hoechst Marion Roussel, Inc.
Supplemental agents for comfort or relief of specific symptoms (loperamide for diarrhea, dicyclomine for cramping, ondansetron for nausea) may be useful when standard treatment with [alpha]-adrenergic agonists (clonidine, guanfacine, lofexidine) do not provide full relief.
Supplemental agents (for comfort or relief of specific symptoms such as loperamide for diarrhea, dicyclomine for cramping, NSAIDS for general aches, ondansetron for nausea) may be useful when standard treatment with [alpha]-adrenergic agonists (clonidine, guanfacine, lofexidine) do not provide full relief.
The agents--available under numerous trade names--include atropine, belladonna, dicyclomine, glycopyrrolate, L-hyoscyamine, mepenzo-late, methscopolamine, propantheline, and scopolamine.
OTC Bulletin Board: LANN) a manufacturer and distributor of pharmaceutical products, announced today that it has received FDA approval to market Dicyclomine HCl Tablets USP, 20 mg Dicyclomine HCl Tablets 20 mg shipments will begin immediately.
The agents--available under many trade names--include atropine, belladonna, dicyclomine, glycopyrrolate, L-hyoscyamine, mepenzolate, methscopolamine, propan-theline, and scopolamine.
Surveillance studies with dicyclomine have noted an increased incidence of birth defects, but because there is no clustering of specific defects, there may be no association, and the risk is considered low.
In addition, the Company received an `AB' rating for Dicyclomine Hydrochloride USP, 10 mg capsules, the Company's largest product, making it fully interchangeable with Marion Merrell Dow's Bentyl(R) and fully reimbursable under Federal Government programs.
The antispasmodic agents hyoscyamine and dicyclomine may give symptomatic relief of cramps and diarrhea, but there are insufficient data to make a recommendation about their use.
OTC) ("LANN"), a manufacturer and distributor of pharmaceutical products, announced today that it has received from the FDA an "AB" rating for Dicyclomine Hydrochloride USP, 10-mg capsules, the company's largest product, making it fully interchangeable with Marion Merrell Dow's Bentyl(R) and fully reimbursable under Federal Government programs.
Misoprostol is contraindicated during pregnancy and dicyclomine is contraindicated for nursing women.
First Half Fiscal 1995 results were sparked by the reintroduction of Dicyclomine in First Quarter 1995 and reflect initial sales to fill channels of distribution for this product.