dicumarol


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dicumarol

 [di-koo´mah-rol]
a coumarinanticoagulant that acts by inhibiting the synthesis of vitamin K–dependent coagulation factors (prothrombin and factors VII, IX, and X) and proteins C and S in the liver; used in the prevention and treatment of thromboembolic disorders.

di·cu·ma·rol

(dī-kū'mă-rol),
An anticoagulant that acts in the liver to block synthesis of vitamin K and vitamin K-dependent coagulation factors; discovered as the causative agent in spoiled hay, which caused bleeding in cattle (sweet clover disease).
See also: warfarin.

dicumarol

/di·cu·ma·rol/ (di-koo´mah-rol) a coumarinanticoagulant, which acts by inhibiting the hepatic synthesis of vitamin K–dependent coagulation factors.

dicumarol

[dīkyo̅o̅′mərol]
an anticoagulant coumarin derivative.
indications It is prescribed for the prophylaxis and treatment of thrombosis and embolism.
contraindications Risk of hemorrhage, peptic ulcer, ulcerative colitis, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are GI disturbances, nausea, bleeding, and diarrhea.

di·cu·ma·rol

(dī-kū'mă-rol)
An anticoagulant that acts in the liver to block synthesis of vitamin K and vitamin K-dependent coagulation factors; discovered as the causative agent in spoiled hay, which caused bleeding in cattle (sweet clover disease).
See also: warfarin

dicumarol

rapid-acting anticoagulant agent

dicoumarol, dicumarol

a potent anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent clotting factors (prothrombin and factors VII, IX and X) in the liver; used in the prevention and treatment of thromboembolic disorders. Produced naturally by conversion of nontoxic coumarin in moldy sweet clover hay, lespepeza hay or sweet vernal hay. Eating the hay causes blood loss due to spontaneous hemorrhage. Formerly called bishydroxycoumarin. See also melilotus, anthoxanthum odoratum lespedeza.
References in periodicals archive ?
Then, 7-ethoxyresorufin (2 [micro]M, Sigma-Aldrich Chemie GmbH, Deisenhofen, Germany; dissolved in DMSO) and dicumarol (10 [micro]M; Sigma-Aldrich Chemie GmbH) were added, and cells were incubated at 37[degrees]C for 4 hr and centrifuged for 5 min (1,200 x g, 4[degrees]C).
The control of dicumarol therapy and the quantitative determination of prothrombin and proconvertin.
8, containing 40 [micro]M dicumarol, and 50 [micro]L of a 20 [micro]M stock solution of ethoxyresorufin with 1.