dicumarol /di·cu·ma·rol/ (di-koo´mah-rol) a coumarinanticoagulant, which acts by inhibiting the hepatic synthesis of vitamin K–dependent coagulation factors.
dicumarol
dicumarol [di-koo´mah-rol]
di·cu·ma·rol (d -k  m -rôl , -r l)n. An anticoagulant that inhibits the formation of prothrombin in the liver. Also called bishydroxycoumarin. |
dicumarol
[dīkyo̅o̅′mərol]
an anticoagulant coumarin derivative.
indications It is prescribed for the prophylaxis and treatment of thrombosis and embolism.
contraindications Risk of hemorrhage, peptic ulcer, ulcerative colitis, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are GI disturbances, nausea, bleeding, and diarrhea.
dicumarol [di-koo´mah-rol]
a coumarinanticoagulant that acts by inhibiting the synthesis of vitamin K–dependent coagulation factors (prothrombin and factors VII, IX, and X) and proteins C and S in the liver; used in the prevention and treatment of thromboembolic disorders.
dicoumarol, dicumarol
a potent anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent clotting factors (prothrombin and factors VII, IX and X) in the liver; used in the prevention and treatment of thromboembolic disorders. Produced naturally by conversion of nontoxic coumarin in moldy sweet clover hay, lespepeza hay or sweet vernal hay. Eating the hay causes blood loss due to spontaneous hemorrhage. Formerly called bishydroxycoumarin. See also melilotus, anthoxanthum odoratum lespedeza.
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