dicoumarol


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Related to dicoumarol: coumarin, Phenindione

dicoumarol

An oral anticoagulant drug now mainly used as a rat poison. Other more readily controllable coumarins, such as WARFARIN, are now used.

dicoumarol, dicumarol

a potent anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent clotting factors (prothrombin and factors VII, IX and X) in the liver; used in the prevention and treatment of thromboembolic disorders. Produced naturally by conversion of nontoxic coumarin in moldy sweet clover hay, lespepeza hay or sweet vernal hay. Eating the hay causes blood loss due to spontaneous hemorrhage. Formerly called bishydroxycoumarin. See also melilotus, anthoxanthum odoratum lespedeza.
References in periodicals archive ?
Based on one study published in 1950, dicoumarol is probably also compatible during nursing.
56) Chloramphenicol also appears to inhibit the metabolism of dicoumarol,(57) chlorpropamide,(58) and tolbutamide.
Dicoumarol A chemical that reduces the blood-clotting ability of animals.
Fungal decomposition of sweet clover results in the formation of dicoumarol, which is an anticoagulant, but this does not lead to the conclusion that coumarins, per se, cause bleeding.