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dicoumarol

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dicoumarol, dicumarol
a potent anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent clotting factors (prothrombin and factors VII, IX and X) in the liver; used in the prevention and treatment of thromboembolic disorders. Produced naturally by conversion of nontoxic coumarin in moldy sweet clover hay, lespepeza hay or sweet vernal hay. Eating the hay causes blood loss due to spontaneous hemorrhage. Formerly called bishydroxycoumarin. See also melilotus, anthoxanthum odoratum lespedeza.
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A more significant risk occurs when the plant becomes infected with mould and the coumarin is converted to the more potent anti-coagulant dicoumarol.
Alternative treatments by Boon, Heather; Smith, Michael / A Friend Indeed
Fungal decomposition of sweet clover results in the formation of dicoumarol, which is an anticoagulant, but this does not lead to the conclusion that coumarins, per se, cause bleeding.
Herbal Medicine: A Guide for Health Care Professionals by Cott, Jerry / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
It should be noted, however, that simple coumarmns such as umbelliferone, found in many plants -- including chamomile and passion flower, popular components of herbal teas -- are not notably active anticoagulants; however, dicoumarol, which occurs e.
The Complete Guide to Herbal Medicines. (Book Review) by Awang, Dennis V.C. / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
 
 
 
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