dichlorphenamide

dichlorphenamide /di·chlor·phen·a·mide/ (di″klor-fen´ah-mīd) a carbonic anhydrase inhibitor; used as an adjunct to reduce intraocular pressure in the treatment of glaucoma.

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dichlorphenamide

[dī′klôrfen′əmīd]

a carbonic anhydrase inhibitor.

indications It is prescribed in the treatment of chronic open-angle glaucoma and before surgery for angle-closure glaucoma.

contraindications Liver and adrenocortical insufficiency, kidney failure, hyperchloremic acidosis, depressed sodium or potassium level, pulmonary obstruction, Addison's disease, known or suspected pregnancy, or known hypersensitivity to this drug prohibits its use.

adverse effects Among the more serious adverse reactions are anorexia, GI disturbances, acidosis, ureteral calculus formation, and aplastic anemia.

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dichlorphenamide

a carbonic anhydrase inhibitor used to reduce intraocular pressure in glaucoma.

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carbonic anhydrase inhibitors 

Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.