diazoxide


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diazoxide

 [di″az-ok´sīd]
a rapid-acting antihypertensive agent without diuretic activity; it has a longer duration of action than other rapid-acting antihypertensives, and is administered intravenously in treatment of malignant hypertension. It also inhibits insulin release and is therefore administered orally to treat hypoglycemia due to hyperinsulinism.

diazoxide

/di·az·ox·ide/ (di″az-ok´sīd) an antihypertensive structurally related to chlorothiazide but having no diuretic properties; used for treatment of hypertensive emergencies. Because it inhibits release of insulin, it is also used in hypoglycemia due to hyperinsulinism.

diazoxide

[dī′əzok′sīd]
a vasodilator used as an antihypertensive. It also inhibits insulin release from the pancreas.
indications It is prescribed parenterally for emergency reduction of blood pressure in malignant hypertension and orally in some cases of hypoglycemia.
contraindications Compensatory hypertension (e.g., coarctation of the aorta), cerebral bleeding, or known hypersensitivity to this drug or other thiazides prohibits its use. Caution is advised in heart disease, pregnancy, and impaired kidney function.
adverse effects Among the more serious adverse reactions are tachycardia, sodium and water retention, hyperglycemia, and severe hypotension.
note This drug is for IV use in hospitalized patients only. Severe hypotension may result from its use.

diazoxide

A vasodilator drug used to treat severe high blood pressure (HYPERTENSION) and HYPOGLYCAEMIA. A brand name is Eudemine.

diazoxide

an oral agent that inhibits insulin release, enhances glycogenolysis and inhibits the uptake of glucose; used to treat hypoglycemia due to hyperinsulinism.
References in periodicals archive ?
They confirmed that sufficient amounts of diazoxide crossed the blood-brain barrier to affect potassium channels in the hypothalamus.
Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels.
The hypoglycemia in patients with GDH-HI is easily controlled with diazoxide.
Surgery is the only curative treatment, and palliation can be achieved with octreotide, diazoxide, chemotherapeutic agents, and radioablation.
About DCCR DCCR is a proprietary crystalline salt of diazoxide formulated as a controlled-release, once-a-day tablet.
Morphine hydrochloride, atropine, methylene blue, pilocarpine, yohimbine, diazoxide, acetyl salicylic acid, glibenclamide, diazepam, pentobarbital sodium and naloxone were dissolved in physiological saline (0.
6A, B and E, when RIN-m5F cells were dialyzed with 1 mM ATP via the recording pipette and stimulated by extracellular addition of 100 [mu]M diazoxide ([K.
The following drugs may decrease the effectiveness of insulin, resulting in hyperglycemia: acetazolamide, albuterol, asparaginase, calcitonin, corticosteroids, cyclophosphamide, danazol, dextrothyroxine, diazoxide, diltiazem, diuretics, dobutamine, epinephrine, estrogens, ethacrynic acid, HIV antivirals, isoniazid, lithium, morphine, niacin, oral contraceptives, phenothiazines, phenytoin, somatropin, terbutaline, thiazide diuretics, and thyroid supplements.
June 27, 2014 /PRNewswire/ -- Essentialis announced today the dosing of the first patient in clinical study PC025, which is designed to evaluate the safety and efficacy of diazoxide choline controlled release tablets (DCCR) in obese Prader-Willi syndrome patients.
The following drugs may decrease the effectiveness of the sulfonylureas, resulting in hyperglycemia: beta blockers, calcium channel blockers, cholestyramine, corticosteroids, diazoxide, estrogens, hydantoins, isoniazid, nicotinic acid, oral contraceptives, phenothiazines, rifampin, sympathomimetics, thiazide diuretics, thyroid medications, and urinary alkalinizers.
The patent provides extensive protection to Essentialis' lead product, Diazoxide Choline Controlled-Release Tablet (DCCR).