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a rapid-acting antihypertensive agent without diuretic activity; it has a longer duration of action than other rapid-acting antihypertensives, and is administered intravenously in treatment of malignant hypertension. It also inhibits insulin release and is therefore administered orally to treat hypoglycemia due to hyperinsulinism.
diazoxide/di·az·ox·ide/ (di″az-ok´sīd) an antihypertensive structurally related to chlorothiazide but having no diuretic properties; used for treatment of hypertensive emergencies. Because it inhibits release of insulin, it is also used in hypoglycemia due to hyperinsulinism.
a vasodilator used as an antihypertensive. It also inhibits insulin release from the pancreas.
indications It is prescribed parenterally for emergency reduction of blood pressure in malignant hypertension and orally in some cases of hypoglycemia.
contraindications Compensatory hypertension (e.g., coarctation of the aorta), cerebral bleeding, or known hypersensitivity to this drug or other thiazides prohibits its use. Caution is advised in heart disease, pregnancy, and impaired kidney function.
adverse effects Among the more serious adverse reactions are tachycardia, sodium and water retention, hyperglycemia, and severe hypotension.
note This drug is for IV use in hospitalized patients only. Severe hypotension may result from its use.
diazoxideA vasodilator drug used to treat severe high blood pressure (HYPERTENSION) and HYPOGLYCAEMIA. A brand name is Eudemine.
an oral agent that inhibits insulin release, enhances glycogenolysis and inhibits the uptake of glucose; used to treat hypoglycemia due to hyperinsulinism.