diazoxide


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diazoxide

 [di″az-ok´sīd]
a rapid-acting antihypertensive agent without diuretic activity; it has a longer duration of action than other rapid-acting antihypertensives, and is administered intravenously in treatment of malignant hypertension. It also inhibits insulin release and is therefore administered orally to treat hypoglycemia due to hyperinsulinism.

diazoxide

/di·az·ox·ide/ (di″az-ok´sīd) an antihypertensive structurally related to chlorothiazide but having no diuretic properties; used for treatment of hypertensive emergencies. Because it inhibits release of insulin, it is also used in hypoglycemia due to hyperinsulinism.

diazoxide

[dī′əzok′sīd]
a vasodilator used as an antihypertensive. It also inhibits insulin release from the pancreas.
indications It is prescribed parenterally for emergency reduction of blood pressure in malignant hypertension and orally in some cases of hypoglycemia.
contraindications Compensatory hypertension (e.g., coarctation of the aorta), cerebral bleeding, or known hypersensitivity to this drug or other thiazides prohibits its use. Caution is advised in heart disease, pregnancy, and impaired kidney function.
adverse effects Among the more serious adverse reactions are tachycardia, sodium and water retention, hyperglycemia, and severe hypotension.
note This drug is for IV use in hospitalized patients only. Severe hypotension may result from its use.

diazoxide

A vasodilator drug used to treat severe high blood pressure (HYPERTENSION) and HYPOGLYCAEMIA. A brand name is Eudemine.

diazoxide

an oral agent that inhibits insulin release, enhances glycogenolysis and inhibits the uptake of glucose; used to treat hypoglycemia due to hyperinsulinism.
References in periodicals archive ?
The insulin releasing mechanism of MFME was ascertained in the presence of diazoxide (0.
During the trial, patients will take five doses of diazoxide choline controlled release tablets over a period of ten weeks as an open label treatment, followed by a four week double-blind, placebo-controlled, randomised withdrawal phase during which half of the patients will be randomised to continue on diazoxide choline controlled release tablets, and half will be using a placebo.
Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results.
KCOs like minoxidil, diazoxide, nicorandil, pinacidil, cromakalim and levcromakalim act by enhancing the ATPase activity of SUR1 subunit and the resultant channel opening causes hyperpolarization (Fig.
The dominantly inherited mutations retain responsiveness to diazoxide.
Presentation with ketoacidosis at onset of diabetes is more common in children aged younger than 4 years, those from lower socioeconomic backgrounds, children who don't have a first-degree relative with diabetes, and children on high-dose corticosteroids, diazoxide, immunosuppressive agents, or an atypical antipsychotic drug.
Other less frequently prescribed drugs include mecamylamine (Inversine), trimetheaphan, diazoxide (Hyperstat), nitroprusside, and hydralazine (Apresoline).
Other drugs may decrease the hypoglycemic effect of the sulfonylureas including: beta-adrenergic blockers, charcoal, cholestyramine, diazoxide, hydantoins, rifampin, thiazide diuretics, and urinary alkalinizers.
When my small patient, in whom nesidioblastosis had been newly diagnosed,[3] was returned to my care, little was needed but to follow along with the suggested treatment of diazoxide.
Among the other mitochondria-targeted compounds with different mode of penetrance and action that are worth mentioning is diazoxide, the opener of mitochondrial [K.
M2 EQUITYBITES-July 1, 2014-Essentialis doses first patient in diazoxide choline clinical trial