diazoxide


Also found in: Dictionary, Thesaurus, Wikipedia.

diazoxide

 [di″az-ok´sīd]
a rapid-acting antihypertensive agent without diuretic activity; it has a longer duration of action than other rapid-acting antihypertensives, and is administered intravenously in treatment of malignant hypertension. It also inhibits insulin release and is therefore administered orally to treat hypoglycemia due to hyperinsulinism.

diazoxide

/di·az·ox·ide/ (di″az-ok´sīd) an antihypertensive structurally related to chlorothiazide but having no diuretic properties; used for treatment of hypertensive emergencies. Because it inhibits release of insulin, it is also used in hypoglycemia due to hyperinsulinism.

diazoxide

[dī′əzok′sīd]
a vasodilator used as an antihypertensive. It also inhibits insulin release from the pancreas.
indications It is prescribed parenterally for emergency reduction of blood pressure in malignant hypertension and orally in some cases of hypoglycemia.
contraindications Compensatory hypertension (e.g., coarctation of the aorta), cerebral bleeding, or known hypersensitivity to this drug or other thiazides prohibits its use. Caution is advised in heart disease, pregnancy, and impaired kidney function.
adverse effects Among the more serious adverse reactions are tachycardia, sodium and water retention, hyperglycemia, and severe hypotension.
note This drug is for IV use in hospitalized patients only. Severe hypotension may result from its use.

diazoxide

A vasodilator drug used to treat severe high blood pressure (HYPERTENSION) and HYPOGLYCAEMIA. A brand name is Eudemine.

diazoxide

an oral agent that inhibits insulin release, enhances glycogenolysis and inhibits the uptake of glucose; used to treat hypoglycemia due to hyperinsulinism.
Mentioned in ?
References in periodicals archive ?
The insulin releasing mechanism of MFME was ascertained in the presence of diazoxide (0.
Insulinotropic Activity of Methanolic Extract of Mesua ferrea Linn
During the trial, patients will take five doses of diazoxide choline controlled release tablets over a period of ten weeks as an open label treatment, followed by a four week double-blind, placebo-controlled, randomised withdrawal phase during which half of the patients will be randomised to continue on diazoxide choline controlled release tablets, and half will be using a placebo.
Essentialis doses first patient in diazoxide choline clinical trial
Hawkins and her team then repeated this in rats, again giving diazoxide orally, achieving similar results.
Brain 'key player in regulating blood sugar in humans'
KCOs like minoxidil, diazoxide, nicorandil, pinacidil, cromakalim and levcromakalim act by enhancing the ATPase activity of SUR1 subunit and the resultant channel opening causes hyperpolarization (Fig.
Potassium channels in health, disease & development of channel modulators
The dominantly inherited mutations retain responsiveness to diazoxide.
Hyperinsulinism in infancy and childhood: when an insulin level is not always enough
Presentation with ketoacidosis at onset of diabetes is more common in children aged younger than 4 years, those from lower socioeconomic backgrounds, children who don't have a first-degree relative with diabetes, and children on high-dose corticosteroids, diazoxide, immunosuppressive agents, or an atypical antipsychotic drug.
Putting a dent in diabetic ketoacidosis
He was well controlled on diazoxide 100 mg taken orally 3 times per day.
Nesidioblastosis coexisting with islet cell tumor and intraductal papillary mucinous hyperplasia. (Case Reports)
Other less frequently prescribed drugs include mecamylamine (Inversine), trimetheaphan, diazoxide (Hyperstat), nitroprusside, and hydralazine (Apresoline).
Autonomic dysreflexia
Other drugs may decrease the hypoglycemic effect of the sulfonylureas including: beta-adrenergic blockers, charcoal, cholestyramine, diazoxide, hydantoins, rifampin, thiazide diuretics, and urinary alkalinizers.
Pharmaceutical care of patients with diabetes
When my small patient, in whom nesidioblastosis had been newly diagnosed,[3] was returned to my care, little was needed but to follow along with the suggested treatment of diazoxide.
One in a million: when extraordinary cases occur in an ordinary practice
Among the other mitochondria-targeted compounds with different mode of penetrance and action that are worth mentioning is diazoxide, the opener of mitochondrial [K.
Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury
M2 EQUITYBITES-July 1, 2014-Essentialis doses first patient in diazoxide choline clinical trial
Essentialis doses first patient in diazoxide choline clinical trial

Medical browser ?
Full browser ?