Nevertheless, it was not clear whether dianthrones are bioavailable at all and contribute to the overall effects of this important medicinal plant.
Dianthrones are not natively present compounds but formed enzymatically in the plant during drying at low temperatures (Wagner, 1999).
What remains unclear is the question whether the natively present dianthrones (most important are sennosides A and B, and their aglyca; Fig.
In this study, the Caco-2 model was utilized to investigate the intestinal permeability of major Senna dianthrones.
For the analysis of dianthrones a new method was developed in-house, utilizing a Luna C18(2) column (150 x 4.
Because of the widespread use of Senna preparations, this study was undertaken to investigate the intestinal transport and uptake of dianthrones, the laxatives natively present in this plant.
At the end of the experiments (after 5 h), the cells were extracted with methanol and analyzed for possible remains of the dianthrones.
Tekel'ova D, Repcak M, Zemkova E, Toth J (2000) Quantitative changes of dianthrones
, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum.