dialysis-related amyloidosis


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dialysis-related amyloidosis

Abbreviation: DRA.
The accumulation of beta-2-microalbumin, a type of albumin, in the blood of patients undergoing hemodialysis. The molecule is not readily removed from the blood by some dialysis membranes, and, when the protein builds up in joints and bones, it can cause pain and loss of function, esp. at the wrist, where it produces carpal tunnel syndrome.
See also: amyloidosis
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This protein aggregates to form amyloid fibrils in osteoarticular tissues, leading to pathological bone destruction and the condition known as dialysis-related amyloidosis (DRA).