dextrorphan


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dextrorphan

(dĕks-trōr'fan),
A metabolite of dextromethorphan.
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6 [micro]M) and CYP2D6-mediated dextrorphan formation ([IC.
MA weakly inhibited CYP1A2-mediated paracetamol formation and CYP2D1-mediated dextrorphan formation only at the highest concentration 100 [micro]M (Fig.
The oxidative phenotype assignment for the population sample was based on the value of the subject's molar urinary ratio of dextromethorphan to dextrorphan (metabolic ratio) in relation to the anti-mode.
The mean dextromethorphan and dextrorphan urinary concentrations in addition to the standard deviations (SD) were computed for extensive and poor metabolizer groups independently.
Individual pharmacokinetic parameters of poor and extensive metabolizers, consisting of the urinary dextromethorphan and dextrorphan concentrations as well as the urinary metabolic ratios along with their means and standard deviations are displayed in Table 1.
Phenacetin, paracetamol, metacetamol, furafylline, testosterone, 6[beta]-hydroxytestosterone, corticosterone, ketoconazole, chlorpropamicle, chlorpheniramine, dextrorphan, dextromethorphan, chlorzoxazone, 6-hydroxychlorzoxazone, sodium diethyl-dithiocarbamate, n-glucose 6-phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beta]-nicotinamide adenine dinucleotide phosphate (NADP), and Tris-HC1 were pur-chased from Sigma Chemical Co.
Dextrorphan, dextromethorphan and chlorpheniramine (internal standard) were separated on Agilent ZORBAX Eclipse XDB-C8, 5[micro]M (150 mm x 4.