dextromethorphan


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Related to dextromethorphan: Dextromethorphan hydrobromide, Doxylamine succinate

dextromethorphan

 [dek″stro-meth´or-fan]
a synthetic morphine derivative used as an antitussive in the form of the hydrobromide salt.

dextromethorphan

/dex·tro·meth·or·phan/ (-meth-or´fan) a synthetic morphine derivative used as an antitussive; used in the form of the base or as the hydrobromide salt or sulfonated styrene-divinylbenzene (polistirex) copolymer.

dextromethorphan

(dĕk′strō-mə-thôr′făn)
n.
An antitussive drug, C18H25NO, that is used in its hydrobromide form and is less addictive than codeine.

dextromethorphan

DXM, poor man's Ecstasy Substance abuse A opiate in some cough syrups which, in megadoses required to get the desired mind-altering effect, has many of the effects of Ecstasy–eg euphoria, hallucinations Route Oral Pharmacologic effects ↓ Cough-center response; mimics codeine's effects without analgesia Uses Suppresses nonproductive cough Toxicity Respiratory depression, coma, death. See Ecstasy, Roboing.

dextromethorphan

An opioid drug, with little useful pain-killing action, used to control persistent and unproductive cough. The drug is on the WHO official list.

dextromethorphan

a synthetic morphine derivative used as an antitussive in the form of the hydrobromide salt.
References in periodicals archive ?
Molecular docking of cryptotanshinone, dihydrotanshinone, tanshinone I, tanshinone IIA dextromethorphan, quinidine to CYP2D6 was performed using the three dimensional (3-D) crystal structure of substrate free CYP2D6 (PDB code 2F9Q) obtained from the Protein Data Bank (Rowland et al.
Instead, the findings open the door to evaluating the effects of dextromethorphan on fibromyalgia and other conditions marked by heightened pain sensitivity, according to Staud, an associate professor of medicine at the University of Florida in Gainesville.
But she says her son's dextromethorphan overdose taught her a universal response.
Web sites contain recipes for making dextromethorphan cough syrups more palatable, with instructions on how to extract it from Sucrets lozenges, Dr.
The extent of dextromethorphan abuse is likely far greater than that reported here, because often only the severest cases are called in to the poison control system and because laboratory testing for the drug is not routinely available in most hospitals, Dr.
About AVP-786 AVP-786, the company's next-generation compound, is a novel investigational drug product consisting of a combination of deuterium modified dextromethorphan (an uncompetitive NMDA receptor antagonist, sigma-1 receptor agonist and inhibitor of the serotonin transporter (SERT) and norepinephrine (NET) transporter) and ultra-low dose quinidine (a CYP2D6 enzyme inhibitor).
patent, the company has exclusive rights to a family of patents and patent applications that claim methods of treating PBA, chronic pain, as well as other neurologic conditions, using combinations of dextromethorphan and quinidine, the two active agents in Zenvia.
2) Supply And Safe Delivery Of Any One Of The Following Medicines- Syp-Antitussive With Expectorants Cough Syrup - Containing Minimum Strength/Ingredient In Each 5mlof Following: Dextromethorphan 10 + Gu Aiphenesin 50mg+Phenylephrine 25mg+Chlorpheniramine Maleate 4mg-100ml.
Zenvia is a combination of two well-characterized compounds: the therapeutically active ingredient dextromethorphan and the enzyme inhibitor quinidine, which serves to increase the bioavailability of dextromethorphan.
AVP-786, the company's next-generation AVP-923 compound, is a novel investigational drug product consisting of a combination of deuterium modified dextromethorphan (an uncompetitive NMDA receptor antagonist, sigma-1 receptor agonist and inhibitor of the serotonin transporter (SERT) and norepinephrine (NET) transporter) and ultra-low dose quinidine (a CYP2D6 enzyme inhibitor).
Poster Presentation Details: Title: PRISM II: An Open-Label Study to Assess the Safety, Tolerability, and Effectiveness of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA) in Pseudobulbar Affect (PBA) Secondary to Dementia, Stroke, or Traumatic Brain Injury (TBI): Early Results of the Alzheimer's Disease/Dementia Cohort
As part of the multi-dose phase of the study, the extent to which CTP-347 inhibits the drug-metabolizing enzyme, CYP2D6, was evaluated by co-dosing subjects with dextromethorphan, which is metabolized by CYP2D6.