dextran sulfate


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dex·tran sul·fate

the sodium salt of sulfuric acid esters of the polysaccharide dextran; it contains not less than 10 units per mg and not less than 14% of sulfate; an anticoagulant.

dextran sulfate

A high-molecular weight, branched-chain polysaccharide polymer of d-glucose that is permeable to water and forms a viscid gelatinous material; it is synthesised commercially or naturally by glycosyl transferases on the surface of certain bacteria, and had been claimed to have anti-HIV activity (by inhibiting HIV-1 and HIV-2 binding to CD4+ cells). Therapeutic trials  showed no such efficacy.

dextran

a water-soluble polysaccharide of glucose (dextrose) produced by the action of Leuconostoc mesenteroides on sucrose; used as a plasma volume extender. Several preparations of dextran are used as anticoagulants.

dextran 40
used as an adjuvant in blood transfusion, an anticoagulant.
dextran sulfate
used as an anticoagulant and recently investigated for its antiviral activity.
References in periodicals archive ?
Marine hydroquinone zonarol prevents inflammation and apoptosis in dextran sulfate sodium-induced mice ulcerative colitis.
1 ANNALS OF INTERNAL MEDICINE that dextran sulfate was very poorly absorbed into the blood when administered orally during a clinical trial.
Sun Diagnostics, LLC also offers Dextran Sulfate Sodium Salt, with a molecular weight of approximately 40,000, for laboratory use.
Agarose gel (A and B) and polyacrylamide gel (C and D) electrophoreses of Cc-SP1 and standards chondroitin-6-sulfate (C-6-S, ~ 60 kDa), chondroitin-4-sulfate (C-4-S ~ 40 kDa), dextran sulfate (DexS, ~ 8 kDa) and/or UHEP (~ 14 kDa).
In the present study, we investigated the anti-inflammatory effect in vivo against dextran sulfate sodium (DSS)-induced intestinal inflammation in mice and explored related mechanisms with the THP-1 cell line.
Ultracentrifugation with [beta]-quantification of LDL-C and HDL-C determined by precipitation of the lower fraction with dextran sulfate and [Ca.
Busso and Lionel Resnick tested zidovudine given with each of three different molecular forms of the experimental AIDS drug dextran sulfate on two different laboratory isolates of HIV.
The study evaluated the efficacy of VB-201 in three mouse models of IBD: trinitrobenzene sulfonic acid (TNBS)-induced colitis, T cell-induced colitis and dextran sulfate sodium (DSS)-induced colitis.
Orally administered [gamma]-oryzanol and CAF also ameliorated colonic inflammation induced by sodium dextran sulfate (Islam et al.