dextran sulfate


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dex·tran sul·fate

the sodium salt of sulfuric acid esters of the polysaccharide dextran; it contains not less than 10 units per mg and not less than 14% of sulfate; an anticoagulant.

dextran sulfate

A high-molecular weight, branched-chain polysaccharide polymer of d-glucose that is permeable to water and forms a viscid gelatinous material; it is synthesised commercially or naturally by glycosyl transferases on the surface of certain bacteria, and had been claimed to have anti-HIV activity (by inhibiting HIV-1 and HIV-2 binding to CD4+ cells). Therapeutic trials  showed no such efficacy.

dextran

a water-soluble polysaccharide of glucose (dextrose) produced by the action of Leuconostoc mesenteroides on sucrose; used as a plasma volume extender. Several preparations of dextran are used as anticoagulants.

dextran 40
used as an adjuvant in blood transfusion, an anticoagulant.
dextran sulfate
used as an anticoagulant and recently investigated for its antiviral activity.
References in periodicals archive ?
In Japan, dextran sulfate is used as an anticoagulant and cholesterol-lowering agent.
Hence we aimed in the current investigation to evaluate the possible modulating effects of HES on ulcerative colitis induced by Dextran Sulfate Sodium (DSS), whose symptoms are more similar to those seen in human UC (Okayasu et al.
The ultracentrifugation (modified [beta]-quantification) procedure requires precipitation of LDL in the bottom fraction with dextran sulfate and [Ca.
Oral administration of RDEA119 was shown to significantly reduce damage to colonic tissue and disease activity in dextran sulfate sodium (DSS) -- induced chronic colitic mice.
The study investigated the efficacy of NU206 in reducing the severity of colitis induced by dextran sulfate sodium (DSS), trinitrobenzene sulfonic acid (TNBS), and by non-steroidal anti-inflammatory drug (NSAID) treatment in interleukin (IL)-10-deficient mice.
HDL-C was repeatedly undetectable (<50 mg/L) in a male who historically had HDL-C values in the 600-800 mg/L range, as determined by manual dextran sulfate precipitation followed by measurement of HDL-C on a BMC (Roche) Hitachi 747, during a time period that coincided with a change in laboratory HDL-C test methodology to the Synchron LX HDL-C (Beckman).
FRC further found that seven of the Paracelsian compounds proved significantly more potent than dextran sulfate, one of the most powerful chemical antimicrobial agents available today for use in topical ointments.
After treatment with ETC-216, the two precipitation methods based on dextran sulfate ([M.
The patent was filed after Canadian Bacterial Diseases Network (CBDN) scientists at British Columbia's Children's Hospital demonstrated, in preliminary laboratory tests, that Dextran Sulfate, manufactured by Polydex Pharmaceuticals, may prevent Pseudomonas thereby preventing the Pseudomonas from causing infection in lungs of cystic fibrosis patients of any age.
The most recent large population data are from the US National Health and Nutrition Examination Survey III (18), which used a dextran sulfate (50 000 Da) with the Mg[Cl.
2+], sulfated [alpha]-cyclodextrin, and dextran sulfate was used to reduce the reactivity of chylomicrons and VLDL-cholesterol (VLDL-C) with the enzymes used in the final reaction.
2], sulfated [alpha]-cyclodextrin, and dextran sulfate, the enzymatic reaction for cholesterol in VLDL and chylomicrons is markedly reduced (reagent 1, cat.