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dexmedetomidine

   Also found in: Wikipedia 0.04 sec.
dexmedetomidine /dex·med·e·to·mi·dine/ (-med-ĕ-to´mĭ-dēn) a selective α agonist, used as the hydrochloride salt as a sedative for patients in intensive care units.
dexmedetomidine,
an alpha2 adrenoceptor agonist sedative.
indications It is used to sedate mechanically ventilated and intubated patients in the intensive care unit.
contraindications Known hypersensitivity to this drug contraindicates its use.
adverse effects Life-threatening effects are atrial fibrillation and infarction. Other serious adverse effects include oliguria, hypertension, pulmonary edema, pleural effusion, hypoxia, leukocytosis, and anemia. Common side effects include nausea, bradycardia, and hypotension.

dexmedetomidine
Anesthesiology A selective α2-adrenoceptor agonist, which ↓ the dose of isoflurane required for anesthesia during abdominal hysterectomy. See Isoflurane.


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Background: We sought to compare the efficacy of midazolam versus dexmedetomidine for sedation during mechanical ventilation in infants and children.
Purpose: This study evaluates the efficacy of dexmedetomidine in clinical scenarios other than sedation during mechanical ventilation.
 
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