dexmedetomidine


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dexmedetomidine

 [deks″med-ĕ-to´mĭ-dēn]
a selective α2-adrenergic receptor agonist, used as the hydrochloride salt as a sedative for patients in intensive care units; administered intravenously.

dexmedetomidine

/dex·med·e·to·mi·dine/ (-med-ĕ-to´mĭ-dēn) a selective α agonist, used as the hydrochloride salt as a sedative for patients in intensive care units.

dexmedetomidine

an alpha2 adrenoceptor agonist sedative.
indications It is used to sedate mechanically ventilated and intubated patients in the intensive care unit.
contraindications Known hypersensitivity to this drug contraindicates its use.
adverse effects Life-threatening effects are atrial fibrillation and infarction. Other serious adverse effects include oliguria, hypertension, pulmonary edema, pleural effusion, hypoxia, leukocytosis, and anemia. Common side effects include nausea, bradycardia, and hypotension.

dexmedetomidine

Anesthesiology A selective α2-adrenoceptor agonist, which ↓ the dose of isoflurane required for anesthesia during abdominal hysterectomy. See Isoflurane.
References in periodicals archive ?
In the Nano Letters study, lead author Changyou Zhan, PhD, a fellow in the LBDD, injected gold nanorod-modified microspheres containing both tetrodotoxin and dexmedetomidine (which prolongs the effects of tetrodotoxin) directly into the footpads of rats and testing the animals' reaction to mechanically-induced pain.
On the basis of product, the market has been segmented in to: Propofol, Sevoflurane, Dexmedetomidine, Desflurane, Remifentanil, Midazolam and Others.
Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarizationactivated cation current.
Furthermore, at the time of data collection, participants with TBI were not receiving any drug known to interfere with BIS signal such as dexmedetomidine or ketamine (Paris et al.
Two days later, the bird was premedicated for surgery with butorphanol (1 mg/kg IM; Dolorex, Intervet, Milsoboro, DE, USA), ketamine (10 mg/ kg IM; Putney, Portland, ME, USA), and dexmedetomidine (0.
Ear tissue samples were obtained from hedgehogs anesthetized with intramuscular ketamine (5 mg/kg) and dexmedetomidine (50 [micro]g/kg).
Third, the trials comparing dexmedetomidine with midazolam and with propofol (5,6).
The rescue protocol combines the intravenous alpha-2 agonist dexmedetomidine with valproic acid.
Isoflurane but not halothane minimum alveolar concentration-sparing response of dexmedetomidine is enhanced in rats chronically treated with selective [alpha]2-adrenoceptor agonist.
4) showed that both dexmedetomidine and ketamine used with propofol were well tolerated in children who required ASD closure.
Dexmedetomidine selectively suppresses dominant behavior in aggressive and sociable mice.
Dexmedetomidine (PreceDEX) has recently been approved as an agent of choice in office sedation.