dexfenfluramine


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dexfenfluramine

Redux® Clinical pharmacology An appetite suppressing amphetamine analogue that acts centrally–ie CNS as an appetite suppressant to ↓ hunger sensation. See Obesity.
References in periodicals archive ?
Lorcaserin, a serotonin receptor agonist similar to fenfluramine and dexfenfluramine but designed to avoid the serotonin-related valvulopathy associated with those drugs, produces significant weight loss compared with placebo, according to a randomized trial of more than 3,000 subjects.
To the best of our knowledge, the concern with the heart valves was limited to fenfluramine and dexfenfluramine," two fen-phen ingredients that were banned from the market in 1997, said Colman, who started in his division 15 years ago as risks from the treatment were emerging.
3 Drug-and toxin-induced PAH, caused by certain drugs and toxins including aminorex, fenfluramine, dexfenfluramine, and toxic rapeseed oil have been associated with the development of PAH.
Likewise, some studies indicated that use of dexfenfluramine and phentermine/fenfluramine was associated with an increase in the prevalence of aortic regurgitation, but was not associated with an increase in the prevalence of mitral regurgitation (9, 10).
Use of diet drugs like fenfluramine and dexfenfluramine can also lead to PAH, and an association between PAH and substance abuse, including methamphetamine, amphetamine, and cocaine use, has also been seen.
Comparison of an ephedrine/caffeine combination and dexfenfluramine in the treatment of obesity.
However, since 1997, fenfluramine, dexfenfluramine and phenylpropanolamine have been removed from U.
Wyeth marketed the dangerous "fen" half of it--the drugs fenfluramine and dexfenfluramine, sold under the brand names Pondimin and Redux.
Ironically, the FDAMA was enacted only two months after the popular diet drugs fenfluramine and dexfenfluramine were withdrawn from the market because of adverse events linked to their off-label use.
Wyeth produced two versions of fenfluramine: Pondimin and a newer chemical cousin, Redux, or dexfenfluramine.
Withdrawal of the popular obesity drugs fenfluramine and dexfenfluramine (Redux) from the U.
The Prescription Drug User Fee Act and FDAMA provisions have had positive effects on accelerated development and expanded access, but several drugs were withdrawn from the market after the new laws (eg, mibefradil, dexfenfluramine, terfenadine, bromfenac, and troglitazone) and debate ensued.