Carbachol-induced tonic contractile activity in longitudinal detrusors
The responses to carbachol at different concentrations in the WKY control detrusors were all lower than those of the SHR control detrusors, showing that SHR was a suitable disease model for detrusor overactivity study (Supplemental Fig.
Detrusor overactivity (DO) was defined as a spontaneously non-volutional detrusor contractions in the storage phase of urodynamic study (11).
Etiological factor, neurological level, lesion severity, presence of TPS and BCR, frequency of storage and emptying dysfunction, and detrusor type of patients are shown in Table 1.
Conclusion: Statistically significant increase was achieved in bladder capacity by SDTENS + oral anticholinergic therapy in patients with SCI who had overactive detrusors, while increase in bladder capacity did not reach level of statistical significance in patients who were treated with oral anticholinergic medication alone in the same treatment duration.
Key Words: Transcutaneous electrical stimulation, overactive detrusor, spinal cord injury
12) found no significant difference between the mean maximum detrusor pressure in the first and second cystometries compared with the third and fourth cystometries, which were performed with 10 minutes intervals between them in a SCI population with overactive detrusors.
Although not performing a third cystometric study with a filling rate of 15 ml/min for comparison with continuous and intermittent cystometric studies with filling rate of 50 ml/min appeared as a limitation of our study, we think that our results are important as they demonstrated advantages of intermittent filling in patients with overactive detrusors.
During fitting, the detrusor actively relaxes white the bladder neck remains contracted so that intravesicular pressure does not exceed outlet resistance.
Contraction of the detrusor increases intravesicular pressure above that of the outlet and micturition occurs.
Hiperaktif detrusor, dusuk mesane kapasitesi, korteksin sakral iseme merkezi uzerindeki inhibisyonunun kaybina bagli istemsiz kontraksiyonlar gorulur.
Suprasakral lezyon: Lezyon pons ve konus medullaris arasinda yer alir (TBH, MSY, transvers miyelit, siringomiyeli), hiperaktif detrusor, detrusor eksternal sfinkter dissinerjisi, yuksek ives.