In 4 randomised double-blinded placebo-controlled studies8101218 200U BTX-A was injected in the intra- detrusor muscle
Botulinum toxin type A injection into the detrusor muscle
was first reported in 2000 and has since been widely studied.
Second, botulinum toxin is known to act on the parasympathetic nervous system by inhibiting release of acetylcholine on nerve endings, including the detrusor muscle
in the bladder.
Over 60 year olds may retain 50-100mls of urine after each void due to decreased contractility of the detrusor muscle
These are functional studies of the LUT and provide information on detrusor muscle
function, capacity and compliance.
Drugs acting on the detrusor muscle
were discontinued three days before the day of appointment.
A person must be able to squeeze the sphincter muscle to prevent urine from leaking out and the detrusor muscle
must stay relaxed so that the bladder can expand.
The bladder (or urinary vesicle) is a hollow organ formed by an inner epithelial layer (the urothetium), connective tissue and the detrusor muscle
Medications called antimuscarinic agents that relax the detrusor muscle
and prevent abnormal contractions are commonly prescribed for OAB.
In the absence of a finding that precludes injection, the injecting physician injects a total of 6 mL of the masked substance into approximately 15 to 20 different detrusor muscle
sites under direct visualization.
Older antimuscarinic drugs lack selectivity for the M3 receptor, which regulates detrusor muscle
function, and often cause collateral blockade of central muscarinic M1 receptors, with resultant cognitive impairment and sleepiness, explained Dr.
the detrusor muscle
contracts); however, the external sphincter also contracts, creating detrusor-sphincter dyssynergia, or uncoordination.