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detoxication |
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detoxification, detoxication 1. reduction of the toxic properties of a substance. 2. treatment designed to assist in recovery from the toxic effects of a drug. metabolic detoxification reduction of the toxic properties of a substance by chemical changes induced in the body, producing a compound which is less poisonous or more readily eliminated. |
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Increased GSTs likely play a role in conjugation and detoxication of lipid peroxides produced by arsenic, but they also play a role for cellular efflux of arsenic via MRP pumps (Leslie et al. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. These authors suggested that rather than CYP1A1 activity enhancing the toxicity of BaP, as has been previously suggested, CYP1A1 is critical for the detoxication of orally administered BaP in mice. |
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detoxication
