of the median line secondary to cocaine abuse.
The etiology of these destructive lesions almost always remains obscure, even after they have been studied in great detail, but they are presumed (perhaps incorrectly) to represent sequelae of intrauterine or perinatal/neonatal ischemia in the brain.
The high incidence of malformative and destructive lesions studied by Frater et al reinforces the impression from pediatric epilepsy surgery centers that these structural changes (sometimes described as neuronal migration disorder [NMD]) most commonly account for intractable epilepsy (including infantile spasms/ West syndrome) in infants and children.
For more destructive lesions
, a microvascular free flap, with or without bone, may be necessary.
One compound in particular, AP24170, demonstrated significant inhibition both of tumor growth and of bone breakdown in the prostate model and a reduction of destructive lesions
in the breast cancer model, consistent with the predicted dual-action profile of such compounds.
Youl BD, Kermode AG, Thompson AJ, et al: Destructive lesions
in demyelinating disease.
Inflammatory pseudotumors are histologically benign but locally destructive lesions
that are usually found in the lung, although some cases of temporal bone involvement have been reported.
Histopathology of the destructive lesions
revealed nonspecific inflammatory cell infiltration with necrosis.
1,2) Non-Hodgkin's lymphomas of the sinonasal tract are an important cause of destructive lesions
of the nose and midface; their course progresses slowly but relentlessly.