Clinical suspicion for Pott's disease should be high for any patient who presents with a destructive lesion
of the spine.
The pathophysiology of cocaine-induced midline destructive lesions
is multifactorial and includes local ischemia secondary to vasoconstriction, chemical irritation from adulterants put in "cut" cocaine, and infection secondary to trauma, impaired mucociliary transport, and decreased humoral and cell-mediated immunity.
In SAPHO syndrome, destructive lesions
progress associated with marginal sclerosis explaining why destructive spondylodiscitis progresses slowly.
There were no bony erosions or destructive lesions
and joint spaces were normal.
Radiologic features vary from undefined destructive lesions
to a well-defined, multilocular appearance.
Knowledge of the clinical and histological behavior of the odontogenic cyst is needed to ensure early detection and prompt treatment of these noncancerous but potentially destructive lesions
Cholesteatomas are non-neoplastic but destructive lesions
consisting of desquamating keratin epithelium.
In addition, immunocompromised patients can have progressive, destructive lesions
requiring medical interventions such as antiviral therapy (9) and surgical debridement (10).
One indication for MRI at midgestation emerges when there are borderline findings on ultrasound, such as those that might be seen with progressive or destructive lesions
that won't be fully realized until late in pregnancy.
The remaining 10 patients underwent intestinal biopsies, 9 of whom showed evidence of hyperplastic or destructive lesions
consistent with CD.
As an alternative to destructive lesions
, much interest is currently directed to the use of stereotactically implanted permanent quadripolar electrodes and impulse generators for deep brain stimulation (DBS).