desquamative interstitial pneumonitis

desquamative interstitial pneumonia

A generally mild, nonspecific interstitial pulmonary reaction that is a double misnomer—as it is neither desquamative nor interstitial—which is characterised by diffuse deposition of haemosiderotic macrophages. DIP is often idiopathic but may be associated with inhalation of inorganic dusts.

Demographics
Most patients are smokers and adults; DIP rarely occurs in children, in whom it has a worse prognosis.

Prognosis
Better prognosis and response to steroids than UIP (in adults).

Imaging
Bilateral ground-glass opacification.
 
DiffDx
Smoking (RBILD), amiodarone therapy, eosinophilic pneumonia, pulmonary alveolar proteinosis.

Management
Corticosteroids.

desquamative interstitial pneumonitis

A nonspecific interstitial pulmonary reaction of adults; DIP is often idiopathic but may be associated with inhalation of inorganic particles  Radiology Bilateral ground-glass opacifications Treatment Corticosteroids. See Diffuse alveolar damage.
References in periodicals archive ?
It should be noted that some cases of congenital PAP may have pathologic findings of desquamative interstitial pneumonitis on transbronchial biopsy, with typical PAP histologic findings only in subpleural areas.
The idiopathic interstitial pneumonias (IIPs) are further divided into seven groups based on pathologic findings: usual interstitial pneumonitis (UIP), nonspecific interstitial pneumonitis (NSIP), desquamative interstitial pneumonitis (DIP), respiratory bronchiolitis-ILD (RB-ILD), acute interstitial pneumonitis (AIP), lymphocytic interstitial pneumonitis (LIP) and bronchiolitis obliterans organizing pneumonia (BOOP).
10) Desquamative interstitial pneumonitis (DIP) has been described in two patients with HCV infection.
Desquamative interstitial pneumonitis is a rare disorder that primarily affects cigarette smokers in their fourth or fifth decade of life.
Desquamative interstitial pneumonitis appears to be a rare complication of hepatitis C virus infection.