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desoxycorticosterone

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desoxycorticosterone [des-ok″sĭ-kor″tĭ-ko-stēr´ōn]
a mineralocorticoid with no glucocorticoid activity, secreted in small amounts by the human adrenal cortex. It is used with a glucocorticoid for replacement therapy in adrenocortical insufficiency and addison's disease and for treatment of salt-losing adrenogenital syndrome.
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In a basic physiologic study that looked at isolated aortas from both normotensive and desoxycorticosterone acetate (DOCA)-salt hypertensive rats, it was found that "changes in extracellular magnesium concentration differentially alter endothelin-1-induced contraction in aortae from normotensive and hypertensive rats, possibly by interfering with calcium utilization during contraction.
Magnesium: Its proven and potential clinical significance by Carter, Cathleen / Southern Medical Journal
Clinical investigation on the use of CoQ for treatment of hypertension began when Igarashi et al (19) reported that CoQ reduced elevated blood pressure in unilaterally nephrectomized rats treated with desoxycorticosterone and saline.
Randomized, Double-Blind, Placebo-Controlled Trial of Coenzyme Q10 in ... by Olson, Richard D. / Southern Medical Journal
 
 
 
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