, gestodene, cyproterone acetate and drospirinone) are clearly second choice behind the second- and first-generation progestins.
After accounting for smoking, obesity, a wide range of other health conditions, alcohol consumption, polycystic ovary syndrome and recent infections, surgeries, leg/hip fractures, and hospital admission, the researchers calculated an increased odds ratio for each hormone: desogestrel
Women using newer pills, containing drospirenone, desogestrel
, gestodene, and cyproterone, had around a four times increased risk of VTE.
The maximum serum concentrations of etonogestrel and ethinyl estradiol were approximately 40 and 30 [micro]g, respectively, compared to the levels with a combined OCP containing 150 jug desogestrel
and 30 [micro]g ethinyl estradiol (13).
Compared with non-users of hormonal contraception, pills with levonorgestrel increase the risk of VTE threefold and pills with drospirenone, desogestrel
or gestodene increase the risk sixfold.
Their safety bulletin says there is a small excess risk with pills containing desogestrel
John's wort, there was a significant decrease in the amount of the desogestrel
present after St.
Comparative profiles of reliability, cycle control, and side effects of two oral contraceptive formulations containing 150 micrograms desogestrel
and either 30 micrograms or 20 micrograms ethinyl estradiol.
28) Oral desogestrel
with testosterone pellets was recently found to lead to azoospermia, but requires daily administration of the progestin and a minor procedure for insertion of pellets.
Second generation pills contain the hormone levonorgestrel, while third generation versions are made with desogestrel
Pills containing gestodene or desogestrel
are not advised for women with increased risk of blood clots such as those with varicose veins or angina.
Similar risks were seen when oral contraceptives containing desogestrel
or gestodene were compared with contraceptives containing levonorgestrel.