Postulated intermediate in cholesterol biosynthesis from lanosterol via zymosterol; accumulates after prolonged administration of substances interfering with cholesterol biosynthesis.
Mentioned in ?
References in periodicals archive ?
A comparative analysis of patients with hypothyroidism (n = 11) and hyperthyroidism (n = 11) showed increased concentrations of the cholesterol precursors desmosterol, lathosterol, and 7-dehydrocholesterol in hyperthyroid patients (Fig.
This was the case for desmosterol and 7-dehydrocholesterol, and sitosterol and lanosterol as well as the known interference from lathosterol and zymosterol.
The mice have a genetic mutation that causes cholesterol to be replaced by a different substance, desmosterol.
Silver fox spermatozoa membranes have significantly higher levels of docosapentaenoic acid (22:5, n-3), higher levels of membrane desmosterol, a nd higher levels of membrane cholesterol as compared to blue fox spermatozoa.
It was postulated that inhibition of lanosterol biosynthesis from squalene could reduce cholesterol levels without a concomitant rise in the levels of the sterol intermediates, lanosterol, zymosterol and desmosterol.
The overall 3-dimensional shape, however, is similar to desmosterol except for the presence of the large benzyl group at position 3.
Several sterol-type compounds circulate along with cholesterol in serum (23), and previous studies have shown that [beta]-sistosterol, campesterol, desmosterol, and lathosterol interfere with AK measurement of cholesterol (4).
This mouse strain was created by disrupting the gene Dhcr24, which encodes the enzyme called desmosterol reductase and appears to be responsible for the last step in the biosynthesis of cholesterol, a sterol that is an indispensable structural block of cells and their membranes and plays major roles in signal transduction.
4, as does desmosterol (3[beta]-hydroxycholest-5,24-diene), another component of amniotic fluid; desmosterol elutes earlier than 7 + 8-DHC, however.
These changes result in the accumulation of desmosterol sulfate, which functions as a potent, endogenous RORgamma agonist.
announced today that, according to their joint research, the amount of plasma desmosterol was found to be highly correlated with longitudinal cognitive decline in patients with Alzheimer's disease.