However despite its relative specificity, Melan-A is often negative in desmoplastic
melanoma and cannot completely replace the use of S-100 for the detection of metastatic melanoma (16).
Felix Ruckert: As mentioned above, the desmoplastic
reaction of the tumor stroma impedes tumor perfusion and therefore accumulation of chemotherapeutics.
Since it was first identified as a variant of malignant melanoma by Conley et al (1) in 1971, desmoplastic
melanoma has presented diagnostic challenges.
He's been battling a rare pelvic tumour, known as a desmoplastic
round cell tumour, at the trust's unit in Newcastle's Great North Children's Hospital and is backing Sarah's venture all the way.
Venkata Ratnam, Head of Aesthetic and Reconstructive Plastic Surgery Department, at NMC Hospital in Abu Dhabi diagnosed what was initially thought to be an ulcer, successfully as Desmoplastic
The most common scenarios in melanoma litigation cases include nodular melanoma being misdiagnosed by a clinician or pathologist, a partial biopsy not capturing the most diagnostically relevant part of the lesion, malignant melanoma being misdiagnosed as a dysplastic or spitz nevus, unrecognized desmoplastic
malignant melanoma, and metastatic malignant melanoma with an unknown primary or recurrence of melanoma (Am.
Chloe Bigmore, of Laleston, near Bridgend, died aged 14 in 2007 after contracting a rare cancer called desmoplastic
round cell sarcoma.
fibroma of bone is a rare intraosseous benign but locally aggressive tumor of connective tissue origin.
Hewitt's research interests include invasion and metastasis of tumors, desmoplastic
reaction, proteases and extracellular matrix and tumor suppression genes.
The presence of such fibroblastic-like stroma, which also includes inflammatory cells, indicates a desmoplastic
reaction (Figure 4A-D).
The tumor was composed of signet ring cells within a desmoplastic
stroma, displaying an Indian file pattern of infiltration (Fig.
Therapies designed to blockade CTGF, such as FG-3019, may beneficially act on the tumor as well as reduce desmoplastic
tissue development and stromal-tumor signaling.