Nguyen VT, Ndove A, Shultz LD, Pittelkow MR, Grando SA: Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.
Ohata Y, Amagai M, Ishii K, Hashimoto T: Immunoreactivity against intracellular domains of desmogleins in pemphigus.
Characterization of autoantibodies in pemphigus using antigen-specific ELISAs with baculovirus expressed recombinant desmogleins.
Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus.
Detection of IgA autoantibodies to desmogleins
by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus.
Desmosomes consist of 2 desmosomal-specific cadherin family members desmogleins
(DSGs) and desmocollins (DSCs).
The classes of agents to be included under the agreement include peptide cadherin antagonist compounds for N-cadherin, E-cadherin, desmogleins
, VE-cadherin and OB-cadherin, as well as Adherex's third generation small molecule, non-peptide cadherin antagonists.
Autoantibody production in pemphigus vulgaris and pemphigus foliaceus is polyclonal, and most circulating autoantibodies against desmogleins are of the IgG4 subclass.
Apparently the positive DIF results seen in perilesional biopsy specimens are due to the presence of IgG1 autoantibodies against desmogleins, which is the predominant subclass of autoantibodies in inactive pemphigus, whereas IgG4 anti-desmoglein autoantibodies are commonly present in acantholytic/preacantholytic sites, and are less likely to be detected by immunohistochemistry in intact perilesional skin.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
Desmoglein 3 protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.
are one of the major glycoproteins of the desmosomal structure found in epithelial cells.