DSG3

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DSG3

A gene on chromosome 18q12.1 that encodes desmoglein 3, a component of intercellular desmosome junctions, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell–cell adhesion. It is expressed in the epidermis, tongue, tonsil and oesophagus.

Molecular pathology
Desmoglein 3 is the antigen targeted in the autoimmune blistering disease pemphigus vulgaris.
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However, in the superficial layers of the skin it is a major protein responsible for cell-to-cell attachment, whereas in the deep epidermis other adhesion molecules are coexpressed, such as desmoglein-3 and Ecadherin, both resistant to lysis by S.
Lung Adenocarcinoma Versus Lung Squamous Cell Carcinoma (Second IHC Panel) Lung Lung Squamous Marker Adenocarcinoma Cell Carcinoma CK7 + -/+ p63 -/+ + SOX2 - + Desmoglein-3 - + Abbreviations: CK7, cytokeratin 7; IHC, immunohistochemical; SOX2, sex-determining region Y box 2; +, greater than 75% of cases are positive; -, fewer than 5% of cases are positive; -/+, fewer than 50% of cases are positive.
Less studied, emerging therapies include intravenous immunoglobulin, plasmapheresis, immunoadsorption, extracorporeal photochemotherapy, cholinergic agonists, rituximab, anti-CD20 monoclonal antibody therapy, tumor necrosis factor-[alpha] (TNF-[alpha]) inhibitors and other experimental therapies such as Desmoglein-3 peptides [10-12].
TTF-1, Napsin A, p63, TRIM 29, Desmoglein-3 and CK5: An Evaluation of Sensitivity and Specificity, and Correlation of Tumor Grade for Lung Squamous Cell Carcinoma vs.
The emergence of novel and better squamous cell carcinoma (SCC) markers, such as p40 and desmoglein-3, coupled with double staining, enhances the possibility of effectively separating adenocarcinoma (ADC) from SCC on small biopsies and cytologic specimens, conserving tissue for molecular testing.
3,6,7,14,15) Brown et al, (3) using antibody cocktails, such as a combination of desmoglein-3 (one of the major glycoproteins of desmosomal structures), CK5, and napsin A, or double labeling with p40 and TTF1, provided diagnostic accuracy with a sensitivity and specificity of 100% in SCCs and sensitivity of 86% and specificity of 100% in ADCs.
Desmoglein-3 and napsin A double stain, a useful immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes.
In the lung and pleural review article, p40, desmoglein-3, desmocollin-3, and cytokeratin (CK) 5 are described as the most effective panel of IHC markers for squamous cell carcinoma; hepatocyte nuclear factor 4 [alpha] (HNF4[alpha]) is demonstrated to be a marker for invasive mucinous adenocarcinoma of the lung; and glucose transporter 1 (Glut1), insulin-like growth factor II messenger RNA-binding protein (IMP3), and cluster of differentiation (CD) 146 are shown to be helpful in differentiating reactive conditions from malignant mesothelial proliferations.
Additional markers for squamous or adenocarcinoma differentiation, such as desmoglein-3 (102) or desmocollin (103) for squamous cell carcinoma or napsin A for adenocarcinoma (103), need further evaluation Abbreviation: NSCLC-NOS, non-small cell lung carcinoma, not otherwise specified.
Antibodies to uroplakin III (UROIII), S100P, and GATA-3 have been shown to be urothelial-associated markers, while expression of CK14 and desmoglein-3 has been associated with squamous differentiation.
The napsin A, S100P, surfactant protein A, UROIII, thrombomodulin, CK14, desmoglein-3, and S100A1 immunostaining procedures were performed at Cedars-Sinai Medical Center with either a BenchMark ULTRA, Leica BONDMAX (Leica Microsystems, Wetzlar, Germany), or Dako Auto-stainer (Dako North America, Inc, Carpinteria, California) automated staining platforms.