DSG2

(redirected from desmoglein-2)

DSG2

A gene on chromosome 18q12.1 that encodes desmoglein 2, a calcium-binding transmembrane glycoprotein component of desmosomes expressed in the colon, in colorectal carcinoma, and in other simple and stratified epithelial-derived cell lines.

Molecular pathology
Defects in DSG2 cause arrhythmogenic right ventricular dysplasia, type 10, and susceptibility to cardiomyopathy dilated type 1BB.
References in periodicals archive ?
Desmoglein-2 (DSG-2): DSG-2 is expressed in cardiac tissue and is an important component of desmosomal complex.
Mutations in desmoglein-2 gene are associated with arrhythmogenic right ventricular cardiomyopathy.