DSG1

(redirected from desmoglein-1)

DSG1

A gene on chromosome 18q12.1 that encodes desmoglein 1, a calcium-binding transmembrane glycoprotein component of desmosomes in epithelial cells, which belongs to the cadherin cell adhesion molecule superfamily.

Molecular pathology
Desmoglein 1 is the antigen targeted in the autoimmune blistering disease pemphigus foliaceus; defects in DSG1 cause palmoplantar keratoderma striate type 1.
References in periodicals archive ?
The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1 and their reduced activity in the skin of ichthyotic patients.
Comparative proteomic profiling has demonstrated that proteins related to skin barrier function (filaggrin-2, corneodesmosin, desmoglein-1, desmocollin-14, and transglutaminase-3) are expressed in significantly lower levels in lesion sites in AD patients [26].
Both ETA and ETB target and destroy desmoglein-1, a molecule found in desmosomes that plays an important role in cell-cell adhesion in the stratum granulosum of the epidermis2.
Applying this hexapeptide to the skin sends cells a signal to produce higher quantities of desmoglein-1.