DSG1

(redirected from desmoglein-1)

DSG1

A gene on chromosome 18q12.1 that encodes desmoglein 1, a calcium-binding transmembrane glycoprotein component of desmosomes in epithelial cells, which belongs to the cadherin cell adhesion molecule superfamily.

Molecular pathology
Desmoglein 1 is the antigen targeted in the autoimmune blistering disease pemphigus foliaceus; defects in DSG1 cause palmoplantar keratoderma striate type 1.
References in periodicals archive ?
Applying this hexapeptide to the skin sends cells a signal to produce higher quantities of desmoglein-1.