desmoglein


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desmoglein

(dĕz″mō-glē′ĭn)
A cell surface molecule typically found in desmosomes that makes skin cells adhere to each other. Autoantibody disruption of cellular adhesion by desmogleins results in pemphigus. Disruption of desmogleins by staphylococcal toxins is responsible for the blistering of the skin seen in staphylococcal scalded skin syndrome.
References in periodicals archive ?
Desmoglein 3 + CK5 showed 100% sensitivity for SCCs, whereas p40 was comparatively less sensitive at 93% for SCCs.
They found that when desmoglein 1 does not properly function or does not exist, the resulting barrier disruption can affect the immune response, and consequences can be severe.
Tacha et al (16) developed a pulmonary panel using immunohistochemistry methods that used a combination of traditional markers such as TTF-1 and p63 and newer, highly sensitive and specific markers such as napsin A and desmoglein 3 to aid in identification of lung SqCC and adenocarcinoma.
1) In PF the autoantibody is to desmoglein 1 (Dsgl), in PV to desmoglein 3 (Dsg3).
Nishifuji K, Nagasaka T, Ota T, Whittock NV, Amagai M: Is desmoglein 4 involved in blister formation in pemphigus or impetigo?
Caspase-dependent cleavage of desmoglein 1 depends on the apoptotic stimulus.
Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients.
The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives.
Autoantibodies found in patients with pemphigus foliaceous are directed against desmoglein (Dsg) 1.
PV arises from an inappropriate immune response of the body to desmoglein 3, a protein that holds skin cells together in normal, healthy skin.
The goal of the therapy is to suppress selectively the production of auto-antibodies against desmoglein 3, a protein on the surface of skin cells.
Detection of IgA autoantibodies to desmogleins by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus.