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a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria; administered orally.


Aerius (CA), Clarinex, Clarinex Reditabs, Neoclarityn (UK)

Pharmacologic class: Peripherally selective piperidine, selective histamine1-receptor antagonist

Therapeutic class: Antihistamine (nonsedating, second generation)

Pregnancy risk category C


Suppresses histamine release at peripheral histamine1-receptor sites


Syrup: 2.5 mg/5 ml

Tablets: 5 mg

Tablets (orally disintegrating): 2.5 mg, 5 mg

Indications and dosages

Seasonal and perennial allergic rhinitis; chronic idiopathic urticaria and allergies caused by indoor and outdoor allergens; pruritus; to reduce number and size of hives

Adults and children ages 12 and older: 5 mg/day P.O.

Children ages 6 to 11: 1 tsp (2.5 mg/5 ml syrup) P.O. once daily

Children ages 12 months to 5 years: ⁄2 tsp (1.25 mg in 2.5 ml syrup) P.O. once daily

Children ages 6 to 11 months: 2 ml (1 mg syrup) P.O. once daily

Dosage adjustment

• Hepatic or renal impairment


• Hypersensitivity to drug, its components, or loratadine


Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12 (safety and efficacy not established, except syrup).


• Give with or without food.

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache

CV: tachycardia, palpitations

EENT: pharyngitis, dry throat

GI: nausea, dyspepsia, dry mouth

GU: dysmenorrhea

Musculoskeletal: myalgia

Other: flulike symptoms, hypersensitivity reaction


Drug-diagnostic tests. Bilirubin, hepatic enzymes: increased values

Skin tests: interference with positive reaction to dermal reactivity indicators

Patient monitoring

• Monitor hepatic and renal function test results.

Patient teaching

• Tell patient he may take drug with or without food.

• Instruct patient to report rapid heartbeat, shortness of breath, rash, persistent flulike symptoms, or muscle ache.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.


a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria. It is administered orally.


A long-acting, low-sedation, ANTIHISTAMINE drug that does not block cardiac potassium channels and is less likely than some second generation antihistamines to have undesirable cardiac effects. It is also less prone to enter the nervous system and produce sedation. A brand name is Neoclarityn.
References in periodicals archive ?
Even though some latest drugs such as desloratadine, rupatadine, azelastine, and mizolastine [31,32] are present in the market, which are proven to have better efficacy compared to drugs such as cetirizine, these drugs were not prescribed at all.
Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria," International Journal of Dermatology, vol.
The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria.
M2 EQUITYBITES-January 28, 2013-Dr Reddy's Laboratories reports availability of Desloratadine ODT in the US(C)2013 M2 COMMUNICATIONS http://www.
M2 PHARMA-January 28, 2013-Dr Reddy's Laboratories reports availability of Desloratadine ODT in the US(C)2013 M2 COMMUNICATIONS
Table 1: Summary of systemic therapeutic alternatives in clinical practice Medication Dose in dialysis Common adverse effects Oral antihistamines Hydroxyzine 10-25 mg po OD-TID Drowsiness, dizziness, dry mouth, weight gain in the long-term Diphenhydramine 25 mg po BID-TID Dimenhydrinate 25-50 mg po BID-TID Loratadine 10 mg po every other day Desloratadine 5 mg po every other day Cetirizine 5 mg po once daily Anti-epileptic Gabapentin 100 mg po post Drowsiness, HD Max: 300mg/day dizziness, fatigue, loss of balance, tremor Pregabalin 25-75 mg po daily Antidepressant 10 mg po BID Sedation, dry mouth, Doxepin urinary retention, constipation, blurred vision, orthostatic hypotension, sexual dysfunction, weight gain
Improvements in simulated real-world relevant performance for patients with seasonal allergic rhinitis: impact of desloratadine.
The objective of this study was to compare efficacy of levocetrizine and desloratadine in once daily dosage in patients suffering from allergic rhinitis.
Second-generation antihistamines are loratadine (Clarityne), desloratadine (Dese-lex), fexofenadine (Telfast), levocetiri-zine dihydrochloride (Xyzal) and certirizine (Zyrtec).
GOTHENBURG, SWEDEN -- Updosing desloratadine by up to fourfold beyond the standard 5 mg for chronic spontaneous urticaria boosted treatment response with no effect on safety, according to the results of a randomized, double-blind controlled trial.
Desloratadine (8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6] -cyclohepta [1,2-b] pyridine) is an oral, non-sedative (Mann et al.
The second-generation agents fexofenadine, loratadine, and desloratadine do not cause sedation at recommended dosafes; however, the latter two can cause sedation at higher dosages.