The venom of this species induces the production of alpha and beta kinases as the expressed and secreted regulator of the activation of normal T lymphocytes (RANTES), the monocyte chemo-attracting protein I (MCP-1), interleukin 8 (IL-8) and the alpha oncogene related to growth (GRO-a) that probably participate in the appearance of dermonecrosis
mediated by neutrophils and T lymphocytes.
Many advances have been made in medical areas in determining the treatment for loxoscelism, epidemiology of envenomations and the physiological mechanism of dermonecrosis.
1994) and Wasserman & Lowry (2005) review the underlying physiological mechanisms of dermonecrosis.
2006) report that there is benefit to using it up to 72 h in that dermonecrosis may still develop but lesion size is smaller and healing time shorter.
This appears to be changing as the medical textbooks are incorporating recent research (in particular, the distribution map of Swanson & Vetter ) along with greater awareness of the differential diagnoses for dermonecrosis especially in regard to MRSA.
Spider bites are prematurely embraced as etiologies for dermonecrosis without proper evidence-based medicine.