dermonecrosis

dermonecrosis

necrosis of the skin.
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LukED is as effective as PVL in rabbit skin samples for dermonecrosis but does not have hemolytic activity or has weak leukocytolitic activity (Kaneko and Kamio, 2004).
La dermonecrosis patognomonica del loxoscelismo esta intimamente relacionadas con la liberacion de polimorfonucleares y la activacion del complemento.
Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis.
Native collagen can suffer an initial effect of collagenase from polymorphonuclear neutrophil leukocytes and seem to play a role in dermonecrosis, partially denaturing this molecule, which then can be sequentially degraded by these gelatinase-like proteases.
The venom of this species induces the production of alpha and beta kinases as the expressed and secreted regulator of the activation of normal T lymphocytes (RANTES), the monocyte chemo-attracting protein I (MCP-1), interleukin 8 (IL-8) and the alpha oncogene related to growth (GRO-a) that probably participate in the appearance of dermonecrosis mediated by neutrophils and T lymphocytes.
Many advances have been made in medical areas in determining the treatment for loxoscelism, epidemiology of envenomations and the physiological mechanism of dermonecrosis.
1994) and Wasserman & Lowry (2005) review the underlying physiological mechanisms of dermonecrosis.
2006) report that there is benefit to using it up to 72 h in that dermonecrosis may still develop but lesion size is smaller and healing time shorter.
5) Sus venenos inducen intensos efectos locales (edema, hemorragia, formacion de bulas, dermonecrosis y mionecrosis) y graves efectos sistemicos que ponen en peligro la vida (desfibrinacion, trombocitopenia, hemorragias en otros organos, nefrotoxicidad).
La fraccion A es la responsable de la dermonecrosis y la actividad letal.
Los efectos toxicos del veneno de Loxosceles intermedia se han asociado con una proteina de 35 kDa (F35), la cual inicialmente se aislo de la fraccion A y presenta actividad de esfingomielinasa y actividad hemolitica dependiente del complemento e inductora de dermonecrosis.
15) El veneno de Loxosceles reclusa induce la produccion de b y a quimoquinas tales como el Regulador Expresado y Secretado de la Activacion de Linfocitos T Normales (RANTES), la proteina quimioatrayente de monocitos 1 (MCP-1), la IL-8 y el Oncogen Relacionado a Crecimiento alfa (GRO--a), las cuales probablemente esten participando en la aparicion de la dermonecrosis mediada por neutrofilos y linfocitos T.